Somatosensory evoked potential (SEP) monitoring during spinal surgery has been associated with a 61% reduction in major neurological deficits. However, visual interpretation of signals is not always accurate, and a significant learning curve has been demonstrated. Therefore, we embarked on a course to develop a novel SEP monitor equipped with the latest in wireless and digital signal processing technology to continuously monitor spinal cord function. We propose the development of a toolbox of techniques which will significantly advance spinal cord assessment during surgery, including: ? Integration of noise reduction via single-sweep rejection and filtering ? Investigation of the coherence of individual spectral components of the SEP and ? Incorporation of wireless multi-channel stimulation & monitoring ? Evaluation of the resulting next-generation real-time monitor in a clinical study It is our vision to translate these hardware and software innovations into a useful device to assist the clinician in improving the outcome of the patient undergoing spinal surgery.
Sherman, D L; Wuyyuru, V; Brooke, M Jason et al. (2010) Spinal cord integrity monitoring by adaptive coherence measurement. J Neurosci Methods 193:90-9 |
Geocadin, Romergryko G; Koenig, Matthew A; Jia, Xiaofeng et al. (2008) Management of brain injury after resuscitation from cardiac arrest. Neurol Clin 26:487-506, ix |
Geocadin, Romergryko G; Eleff, Scott M (2008) Cardiac arrest resuscitation: neurologic prognostication and brain death. Curr Opin Crit Care 14:261-8 |