This grant is to support the acquisition of a high-field small animal imager to support multiple NIH- funded investigators using small animals for biomedical research. The imager selected is a 7T Bruker ClinScan system which incorporates the advantages of Bruker magnet, gradient coil and radiofrequency coil with the expertise and accomplishments of Siemens Medical Solutions to produce the RF electronics and controlling software. That the new imager will operate using syngo software which is the same as used on the Siemens TIM Trio also housed in the Magnetic Resonance Imaging and Spectroscopy Center (MRISC) will facilitate translation of imaging protocols between experimental animals and human research subjects and will aid in the acquisition of optimal imaging protocols on complex studies. The instrument will be installed in and administered by MRISC - a university core facility dedicated to the development of innovative preclinical and experimental MR imaging of experimental animals and humans. The imager will be operated and maintained by a group of experienced MR researchers. The imager will be sited next to the animal colony facility which houses non-human primates, as well as rats and mice used for a variety of research studies. PUBLIC HEALH

Public Health Relevance

This High End Instrumentation Grant will provide a high field, MR imager suitable for small animal in vivo imager to a multi-user group of productive, NIH-funded, biomedical researchers. This instrument will replace the current use of a clinical imager, ill suited for imaging rodents, with a state-of-the-art, high field imager suitable for research into traumatic injury, cancer, cardiovascular and several other areas of research currently underway at the University of Kentucky.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biomedical Research Support Shared Instrumentation Grants (S10)
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Special Emphasis Panel (ZRG1-SBIB-L (30))
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Levy, Abraham
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University of Kentucky
Internal Medicine/Medicine
Schools of Medicine
United States
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Weekman, Erica M; Sudduth, Tiffany L; Caverly, Carly N et al. (2016) Reduced Efficacy of Anti-A? Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity. J Neurosci 36:9896-907
Haggerty, Christopher M; Jing, Linyuan; Fornwalt, Brandon K (2016) Of mice (dogs) and men: getting to the heart of obesity-associated cardiac dysfunction. Diabetologia 59:9-12
Parikh, Ishita; Guo, Janet; Chuang, Kai-Hsiang et al. (2016) Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions. Aging (Albany NY) 8:2814-2826
Patel, Samir P; Smith, Taylor D; VanRooyen, Jenna L et al. (2016) Serial Diffusion Tensor Imaging In Vivo Predicts Long-Term Functional Recovery and Histopathology in Rats following Different Severities of Spinal Cord Injury. J Neurotrauma 33:917-28
Pumphrey, Ashley; Yang, Zhengshi; Ye, Shaojing et al. (2016) Advanced cardiac chemical exchange saturation transfer (cardioCEST) MRI for in vivo cell tracking and metabolic imaging. NMR Biomed 29:74-83
Haggerty, Christopher M; Mattingly, Andrea C; Kramer, Sage P et al. (2015) Left ventricular mechanical dysfunction in diet-induced obese mice is exacerbated during inotropic stress: a cine DENSE cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 17:75
Davis, Frank M; Rateri, Debra L; Balakrishnan, Anju et al. (2015) Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms. Arterioscler Thromb Vasc Biol 35:155-62
Haggerty, Christopher M; Kramer, Sage P; Skrinjar, Oskar et al. (2014) Quantification of left ventricular volumes, mass, and ejection fraction using cine displacement encoding with stimulated echoes (DENSE) MRI. J Magn Reson Imaging 40:398-406
Suever, Jonathan D; Wehner, Gregory J; Haggerty, Christopher M et al. (2014) Simplified post processing of cine DENSE cardiovascular magnetic resonance for quantification of cardiac mechanics. J Cardiovasc Magn Reson 16:94
Kramer, Sage P; Powell, David K; Haggerty, Christopher M et al. (2013) Obesity reduces left ventricular strains, torsion, and synchrony in mouse models: a cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 15:109