As the population ages, the development of strategies to maintain and even enhance neuronal plasticity and cognitive function in the elderly is a critical priority. This training program in the Neurobiology of Aging is designed to provide high quality research training for select pre and postdoctoral students to prepare them for successful independent careers on the basic mechanisms in the neurobiology of aging. The program, begun in 1983, is designed to provide multidisciplinary training to better understand the basic neural events underlying successful aging, its maintenance and plasticity, the key events that compromise higher cognitive function and lead to Alzheimer's disease. To accomplish this we have assembled a group of senior and junior investigators recognized for their expertise in key areas of research, who have a history and continued motivation to collaborate, and are dedicated to high quality training in the field. The program includes preceptors from departments in the Schools of Biological Sciences, Chemistry, Engineering, and Medicine in order to reflect advances in new evolving areas and to train the next generation of researchers. Since the last renewal, the training program has added several new preceptors recently recruited to UCI proving new opportunities for high quality training. The program continues to evolve to include training in several new technologies that range from genomics to transgenic and higher animal models and their application to the neurobiology of aging. In addition, the program offers research opportunities for the study of postmortem human tissues and clinical-pathological studies in order to translate basic findings to the clinical setting. Trainees that enter the program have an opportunity to obtain a well-rounded experience in neurobiology at the same time focus on a subfield of interest. The training program involves hands on experience, a Brain Aging seminar series, specialized didactic training, and individualized training and community awareness. The program has a solid track record of producing quality scientists who enter academia or apply their training and knowledge in industry to address a challenging and serious health problem for the nation and our growing senior population.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZAG1-ZIJ-9 (J1))
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Wise, Bradley C
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University of California Irvine
Internal Medicine/Medicine
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United States
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White, André O; Kramár, Enikö A; López, Alberto J et al. (2016) BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens. Nat Commun 7:11725
Marsh, Samuel E; Abud, Edsel M; Lakatos, Anita et al. (2016) The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A 113:E1316-25
López, Alberto J; Kramár, Enikö; Matheos, Dina P et al. (2016) Promoter-Specific Effects of DREADD Modulation on Hippocampal Synaptic Plasticity and Memory Formation. J Neurosci 36:3588-99
Kim, Steven B; Bartell, Scott M; Gillen, Daniel L (2015) Estimation of a benchmark dose in the presence or absence of hormesis using posterior averaging. Risk Anal 35:396-408
Czerniawski, Jennifer; Miyashita, Teiko; Lewandowski, Gail et al. (2015) Systemic lipopolysaccharide administration impairs retrieval of context-object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation. Brain Behav Immun 44:159-66
Elmore, Monica R P; Lee, Rafael J; West, Brian L et al. (2015) Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation. PLoS One 10:e0122912
Rice, Rachel A; Spangenberg, Elizabeth E; Yamate-Morgan, Hana et al. (2015) Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus. J Neurosci 35:9977-89
Dagher, Nabil N; Najafi, Allison R; Kayala, Kara M Neely et al. (2015) Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice. J Neuroinflammation 12:139
Davtyan, Hayk; Ghochikyan, Anahit; Hovakimyan, Armine et al. (2014) Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines. J Neuroimmunol 268:50-7
Czerniawski, Jennifer; Guzowski, John F (2014) Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus. J Neurosci 34:12470-80

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