This interdisciplinary post-doctoral training program will provide intensive, structured translational research training in Alzheimer's disease (AD) for a new cadre of talented basic PhD, clinical PhD, and physician scientists. Leveraging the existing infrastructure and research strengths of the NIA-funded Boston University Alzheimer's Disease Center and affiliated faculty, the program will eliminate barriers in communication, knowledge, and collaboration between basic and clinical scientists and train investigators to cross disciplinary boundaries at an early and formative period in their professional development. Through individualized and group didactics, the fellowship program will provide (1) integrated knowledge in the basic and clinical fundamentals of AD, focusing on environmental and genetic risk factors, prevention, mechanistic pathways, biomarkers, diagnostics, and therapeutics of AD, (2) training in essential research skills (e.g., conceptualization, development, and implementation of research studies, and creativity in developing new research directions), (3) training in critical professional skills for success in academic medicine (e.g., understanding available funding mechanisms and development of grant writing skills, oral presentation skills, and manuscript writing abilities), (4) training in the responsible conduct of research, emphasizing both animal and human subjects, and (5) a high quality jointly-mentored, interdisciplinary research experience that synthesizes the trainee's knowledge base, research and professional skill set, and appreciation of responsible conduct of research, and prepares the trainee for independence as an investigator. Trainees completing the program will be well-positioned for academic success in both conducting and securing funding for original research in AD. As a consequence, the program will fill an important need for an increased number of high quality investigators who are well equipped to advance the field of AD prevention, diagnostics, and therapeutics.

Public Health Relevance

An estimated 5.1 million Americans have AD, and this number is expected to rise to 13.2 million by 2050. Advances in AD diagnostics and therapeutics rely on innovative translational research efforts;however, a recent report suggests there is a shortage of patient-oriented investigators well-trained in the fundamentals of translational research.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (J2))
Program Officer
Silverberg, Nina B
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston University
Schools of Medicine
United States
Zip Code
Montenigro, Philip H; Alosco, Michael L; Martin, Brett M et al. (2017) Cumulative Head Impact Exposure Predicts Later-Life Depression, Apathy, Executive Dysfunction, and Cognitive Impairment in Former High School and College Football Players. J Neurotrauma 34:328-340
Stern, Robert A; Seichepine, Daniel; Tschoe, Christine et al. (2017) Concussion Care Practices and Utilization of Evidence-Based Guidelines in the Evaluation and Management of Concussion: A Survey of New England Emergency Departments. J Neurotrauma 34:861-868
Aparicio, Hugo J; Petrea, Rodica E; Massaro, Joseph M et al. (2017) Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study. Atherosclerosis 265:305-311
Galetta, Kristin M; Chapman, Kimberly R; Essis, Maritza D et al. (2017) Screening Utility of the King-Devick Test in Mild Cognitive Impairment and Alzheimer Disease Dementia. Alzheimer Dis Assoc Disord 31:152-158
Huber, Bertrand R; Alosco, Michael L; Stein, Thor D et al. (2016) Potential Long-Term Consequences of Concussive and Subconcussive Injury. Phys Med Rehabil Clin N Am 27:503-11
Chapman, Kimberly R; Bing-Canar, Hanaan; Alosco, Michael L et al. (2016) Mini Mental State Examination and Logical Memory scores for entry into Alzheimer's disease trials. Alzheimers Res Ther 8:9
Gifford, Katherine A; Liu, Dandan; Carmona, Hugo et al. (2015) Inclusion of an informant yields strong associations between cognitive complaint and longitudinal cognitive outcomes in non-demented elders. J Alzheimers Dis 43:121-32
Gifford, Katherine A; Liu, Dandan; Romano 3rd, Raymond et al. (2015) Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimers Dement (Amst) 1:429-439
Gifford, Katherine A; Liu, Dandan; Lu, Zengqi et al. (2014) The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults. Alzheimers Dement 10:319-27
Stern, Robert A; Daneshvar, Daniel H; Baugh, Christine M et al. (2013) Clinical presentation of chronic traumatic encephalopathy. Neurology 81:1122-9

Showing the most recent 10 out of 11 publications