This is the second competing renewal of a training program to provide high quality pre- and postdoctoral training in Immunology and Molecular Pathogenesis to the most qualified candidates. The faculty in the graduate Program in Immunology and Molecular Pathogenesis (IMP) have the expertise required to provide the foundation that is critical for outstanding predoctoral and postdoctoral training. Many of the participating faculty have extensive training records, in some cases initiated at their former institutions prior to their recruitment to Emory. The areas of research represented by this program have outstanding potential for future investigations and for providing new insights into disease pathogenesis. The research programs of the faculty fall into three main training areas: 1) pathogenesis of infectious diseases;2) molecular virology;and 3) immunobiology. The faculty of IMP are members of six basic science or clinical departments in the School of Medicine, as well as Yerkes National Primate Center, the Biology Department of Emory College, and the U.S. Centers for Disease Control and Prevention (CDC). During the previous ten years of this training program, this grant has provided support for 48 predoctoral and 13 postdoctoral trainees. Two of the postdoctoral trainees are currently independent investigators (LaJolla Institute of Allergy and Immunology;UCSF) and two others have already received individual training awards to complete their postdoctoral work. Of the 48 predoctoral trainees, 27 are still in predoctoral training. Twenty students have received their Ph.D.s of which 1 is an Assistant Professor, 1 is a CDC staff scientist, 15 and are currently postdoctoral fellows. Of these 48 students supported by the training grant only one has left the program (a nearly 100% retention rate), which is better than the IMP program overall. Therefore this training grant has improved immunology and virology training at Emory, supporting not only our most outstanding students and postdocs, but enriching the intellectual environment by funding external speakers in the Program seminar series.
The relevance for this training program includes the importance of interdisciplinary training in providing the foundation for investigating mechanisms of pathogenesis and the extensive previous involvement of the participating faculty in pre- and postdoctoral training. The availability of funds from this training grant has had a profound positive effect on immunology and virology training at Emory University.
|Laurie, Sonia J; Liu, Danya; Wagener, Maylene E et al. (2018) 2B4 Mediates Inhibition of CD8+ T Cell Responses via Attenuation of Glycolysis and Cell Division. J Immunol 201:1536-1548|
|McMaster, Sean R; Wein, Alexander N; Dunbar, Paul R et al. (2018) Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma. Mucosal Immunol 11:1071-1078|
|Andargachew, Rakieb; Martinez, Ryan J; Kolawole, Elizabeth M et al. (2018) CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection. J Immunol 201:19-30|
|Barwick, Benjamin G; Scharer, Christopher D; Martinez, Ryan J et al. (2018) B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation. Nat Commun 9:1900|
|Shwetank; Abdelsamed, Hossam A; Frost, Elizabeth L et al. (2017) Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent. Immunol Cell Biol 95:953-959|
|Scharer, Christopher D; Bally, Alexander P R; Gandham, Bhanu et al. (2017) Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory. J Immunol 198:2238-2243|
|Cook, D A; Kannarkat, G T; Cintron, A F et al. (2017) LRRK2 levels in immune cells are increased in Parkinson's disease. NPJ Parkinsons Dis 3:11|
|Bally, Alexander P R; Tang, Yan; Lee, Joshua T et al. (2017) Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory. J Immunol 198:205-217|
|Liu, Yang; Blanchfield, Lori; Ma, Victor Pui-Yan et al. (2016) DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity. Proc Natl Acad Sci U S A 113:5610-5|
|Shorter, Shayla K; Schnell, Frederick J; McMaster, Sean R et al. (2016) Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses. PLoS One 11:e0149582|
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