This proposal is a renewal for the training initiative for pre-doctoral training in Tropical Infectious Diseases and requests funding for five trainees for five years. The Principal Investigator is Professor Dyann Wirth, Chair of the Department of Immunology and Infectious Diseases. The training program will be centered at the Department of Immunology and Infectious Diseases at the Harvard School of Public Health (HSPH). According to the World Health Organization, over one third of the deaths in the world in 2005 were due to infectious diseases and this proportion is likely to increase with the spread of HIV/AIDS in developing countries. Thus, there is an increasing need for research and training in infectious diseases. The department has eighteen faculty members who are focused on developing country infectious diseases, specifically on malaria, HIV and tuberculosis. The renewal training program provides for training of predoctoral students in tropical infectious diseases, including training in core knowledge areas of immunology, molecular biology, cell biology, biostatistics, biochemistry, genetics and genomics. Students, in addition, will receive advanced training focusing on specific infectious agents and the applications of modern approaches to vaccine and drug development for these important diseases. Much of the ongoing basic research in the Department of Immunology and Infectious Diseases addresses important areas of molecular pathogenesis, in particular the host-pathogen interfaces. Trainees in this program will be exposed to integrated approaches that consider the host-pathogen relationship at the molecular and cellular levels, incorporating biochemistry and genomics, to generate a more broad perspective on disease pathogenesis and strategies for intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI049928-10
Application #
8298589
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2001-07-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$231,589
Indirect Cost
$11,229
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Shell, Scarlet S; Wang, Jing; Lapierre, Pascal et al. (2015) Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape. PLoS Genet 11:e1005641
Fishbein, S; van Wyk, N; Warren, R M et al. (2015) Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity. Mol Microbiol 96:901-16
Volohonsky, Gloria; Terenzi, Olivier; Soichot, Julien et al. (2015) Tools for Anopheles gambiae Transgenesis. G3 (Bethesda) 5:1151-63
Daniels, Rachel F; Schaffner, Stephen F; Wenger, Edward A et al. (2015) Modeling malaria genomics reveals transmission decline and rebound in Senegal. Proc Natl Acad Sci U S A 112:7067-72
Hamel, Donald J; Sankalé, Jean-Louis; Samuels, Jay Osi et al. (2015) Building laboratory capacity to support HIV care in Nigeria: Harvard/APIN PEPFAR, 2004-2012. Afr J Lab Med 4:
Obaldia 3rd, Nicanor; Baro, Nicholas K; Calzada, Jose E et al. (2015) Clonal outbreak of Plasmodium falciparum infection in eastern Panama. J Infect Dis 211:1087-96
Coll, N S; Smidler, A; Puigvert, M et al. (2014) The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy. Cell Death Differ 21:1399-408
Gabrieli, Paolo; Smidler, Andrea; Catteruccia, Flaminia (2014) Engineering the control of mosquito-borne infectious diseases. Genome Biol 15:535