Infectious diseases remain the major cause of morbidity and mortality worldwide. The study of infectious diseases, including novel discoveries that can lead to prevention or cures, requires a good understanding of both the host and the pathogen. Scientifically, this means the study of host responses to pathogens, which is the field of immunology, and pathogen strategies for causing disease, which is part of the field of microbiology. However, historically immunology and microbiology research has proceeded to some degree along parallel paths. The intersection of these two disciplines is absolutely essential for making progress in the fight against infectious disease. This T32 Training Program, Immunology of Infectious Disease (IID), is designed to bridge the gap between microbiology and immunology research as it applies to infectious disease. Our goal is to train young scientists to be familiar in both fields, and to provide support to those scientists working at the intersection of microbiology and immunology. We have a strong and experienced training faculty from a wide range of departments and schools at the University of Pittsburgh. The IID Training Program supports pre-doctoral students from two programs that sit within the umbrella Interdisciplinary Biomedical Graduate Program: Molecular Virology and Microbiology and Immunology. Post-doctoral scholars from the labs of the training faculty are eligible for support as well. This cross-campus, cross-discipline training program has been successful for the past 10 years, and we have implemented changes to make it even more successful with this renewal application.

Public Health Relevance

IPnrfoegcrtaiomuspdroispeoasestaoretraimnayjourncgauscsieonftimstosr(bgirdaidtyuatnedsmtuodretnaltistyanwdoprlodswt-idoec.tTohraislTferlaloinwins)g icnonthtreibstutdioynofftbhoetihmfmieuldnsotloginyfaenctdiomuiscrdoisbeiaosloegsywoifllirnefesuctltioiunswdeislle-tarsaeisn.eUdnsdceiersntaisntdsiwnghtohe will discover cures and prevention strategies to reduce the global burden of infections.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060525-12
Application #
9326897
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
2005-07-01
Project End
2021-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
12
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Genetics
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Drummond, Coyne G; Bolock, Alexa M; Ma, Congrong et al. (2017) Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner. Proc Natl Acad Sci U S A 114:1672-1677
Flitter, Becca A; Hvorecny, Kelli L; Ono, Emiko et al. (2017) Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc Natl Acad Sci U S A 114:136-141
Li, Jihong; Freedman, John C; Evans, Daniel R et al. (2017) CodY Promotes Sporulation and Enterotoxin Production by Clostridium perfringens Type A Strain SM101. Infect Immun 85:
Freedman, John C; Shrestha, Archana; McClane, Bruce A (2016) Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications. Toxins (Basel) 8:
DiFazio, Robert M; Mattila, Joshua T; Klein, Edwin C et al. (2016) Active transforming growth factor-? is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis. Fibrogenesis Tissue Repair 9:6
Hendricks, Matthew R; Lashua, Lauren P; Fischer, Douglas K et al. (2016) Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity. Proc Natl Acad Sci U S A 113:1642-7
Shrestha, Archana; Hendricks, Matthew R; Bomberger, Jennifer M et al. (2016) Bystander Host Cell Killing Effects of Clostridium perfringens Enterotoxin. MBio 7:
Phuah, Jiayao; Wong, Eileen A; Gideon, Hannah P et al. (2016) Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques. Infect Immun 84:1301-11
Morosky, Stefanie; Lennemann, Nicholas J; Coyne, Carolyn B (2016) BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. J Virol 90:5098-107
Hendricks, Matthew R; Bomberger, Jennifer M (2016) Digging through the Obstruction: Insight into the Epithelial Cell Response to Respiratory Virus Infection in Patients with Cystic Fibrosis. J Virol 90:4258-61

Showing the most recent 10 out of 86 publications