Investment in the training of young scientists in HIV research will be critical to ultimately achieve our ambitious goal of control of the HIV epidemic worldwide. Building upon a successful training grant paradigm over the past 10 years, we reconfigured our HIV translational research training program to address the current research landscape. We emphasize individualized career development plans with focus on critical thinking and methods that prepare trainees for a successful and productive research career. The program is co-directed by clinic- based (Havlir) and laboratory-based (McCune) physician scientists. New features of the program include: a) realignment of focus to NIH high priority HIV research areas including a new implementation science track (T3-4 research) integrated into the high-impact research priority areas; b) expansion of the program faculty to support training and research for our fellows in high priority areas including prevention of new infections; novel therapies and approaches to care delivery; HIV cure; and HIV co- infections/complications with a cross-cutting focus on disparities; c) the addition of 3 R01 funded, recent NIH T32 training program graduates as faculty; d) close integration with UCSF CFAR mentoring programs, with a structured career development program for trainees and specialized training for new mentors; and e) administrative re-organization, a newly-added External Advisory Board f) expanded recruitment strategies. At completion of the program, we expect our graduates to have achieved the following: (1) to have a track record of publications; (2) to be well on their way to becoming productive, independent researchers at an academic or other public or private research entity; (3) to have secured K-level funding, VA career development awards, R21, or R01 funding the scholar stays in academia. We strive to train leading HIV patient-oriented and translational physician scientists and for these leaders to consist of women, men, and persons of diverse racial/ethnic and socioeconomic backgrounds.

Public Health Relevance

Thirty seven million persons are currently living with HIV, and HIV continues to be a major cause of death and suffering worldwide. Our program supports training of early career stage investigators to become independent patient-based and translational scientists addressing the highest impact research questions in HIV. Building on the successful outcomes of our prior training program, we have restructured our program to ensure that we continue to train the next generation of researchers in highly-impactful areas of HIV prevention, treatment and, ultimately, cure.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI060530-11A1
Application #
9200453
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Lawrence, Diane M
Project Start
2005-09-05
Project End
2021-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
11
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Clemenzi-Allen, Angelo; Geng, Elvin; Christopoulos, Katerina et al. (2018) Degree of Housing Instability Shows Independent ""Dose-Response"" With Virologic Suppression Rates Among People Living With Human Immunodeficiency Virus. Open Forum Infect Dis 5:ofy035
Mody, Aaloke; Roy, Monika; Sikombe, Kombatende et al. (2018) Improved Retention With 6-Month Clinic Return Intervals for Stable Human Immunodeficiency Virus-Infected Patients in Zambia. Clin Infect Dis 66:237-243
McDonald, Chloe R; Conroy, Andrea L; Gamble, Joel L et al. (2018) Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy. Clin Infect Dis 66:428-436
Katrak, Shereen; Nayebare, Patience; Rek, John et al. (2018) Clinical consequences of submicroscopic malaria parasitaemia in Uganda. Malar J 17:67
Woodworth, Michael H; Marquez, Carina; Chambers, Henry et al. (2017) Disabling Dactylitis and Tenosynovitis Due to Mycobacterium haemophilum in a Patient With Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome. Open Forum Infect Dis 4:ofx165
Cockerham, Leslie R; Yukl, Steven A; Harvill, Kara et al. (2017) A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals. Pathog Immun 2:310-334
Koss, Catherine A; Natureeba, Paul; Kwarisiima, Dalsone et al. (2017) Viral Suppression and Retention in Care up to 5 Years After Initiation of Lifelong ART During Pregnancy (Option B+) in Rural Uganda. J Acquir Immune Defic Syndr 74:279-284
Spinelli, Matthew A; Frongillo, Edward A; Sheira, Lila A et al. (2017) Food Insecurity is Associated with Poor HIV Outcomes Among Women in the United States. AIDS Behav 21:3473-3477
Brondfield, Max N; Reid, Michael J A; Rutishauser, Rachel L et al. (2017) Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature. Transpl Infect Dis 19:
Prahl, Mary; Jagannathan, Prasanna; McIntyre, Tara I et al. (2017) Sex Disparity in Cord Blood FoxP3+ CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero. Open Forum Infect Dis 4:ofx022

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