Major advances have been made in preventing the occurrence of some infectious diseases (through vaccines and public health measures) and in the treatment of some infectious diseases (through the development of antimicrobial agents). However, infectious diseases remain a major global health threat, and it is clear that there is a significant national need to improve our ability to prevent, detect, and control microbial diseases. To accomplish this goal, it is essential that high quality basic science research be performed in infectious diseases and that our nation trains outstanding people to perform such research. Basic science research is necessary to elucidate the mechanisms by which microbial pathogens cause disease, to elucidate the mechanisms by which the host immune system can successfully defend against microbial pathogens, and to define novel strategies to prevent and/or treat infectious pathogens. The University of Texas Southwestern Medical Center at Dallas has an outstanding group of senior investigators performing basic science research in Infectious Diseases, and is therefore, ideally positioned to train both Ph.D. scientists interested in Infectious Diseases and physicians who are interested in laboratory-oriented research careers in Infectious Diseases. The major goal of our proposal is to provide outstanding laboratory research training in Infectious Diseases to Ph.D. and M.D. postdoctoral fellows so that these individuals may develop into successful independent investigators who will become future leaders in the field. This will be accomplished by providing focused training with outstanding preceptors who conduct state-of-the-art research in different aspects of host-pathogen interactions, by providing 1) a highly stimulating multidisciplinary environment for research, 2) close supervision and support from training grant faculty, and 3) didactic training in both practical aspects of research and career development (e.g., ethics, biostatistics, manuscript and grant writing, patent and proprietary issues) as well as didactic training in diverse areas of science (e.g., current topics at the interface of host-pathogen interactions, immunology, cell biology, molecular biology, virology) that will enrich their research training experience and enhance the quality of their research. Together with the outstanding scientific environment at UT Southwestern, this multi-faceted approach to training post-doctoral fellows in Infectious Diseases research will produce an outstanding group of young investigators with strong potential to make valuable contributions to the global prevention and/or treatment of infectious diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI070116-04
Application #
7857942
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2007-09-30
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
4
Fiscal Year
2010
Total Cost
$115,293
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
De Nisco, Nicole J; Orth, Kim; VanHook, Annalisa M (2017) Science Signaling Podcast for 16 May 2017: Vibrio rewires host cells. Sci Signal 10:
De Nisco, Nicole J; Kanchwala, Mohammed; Li, Peng et al. (2017) The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways. Sci Signal 10:
Robinson, Christopher M; Wang, Yao; Pfeiffer, Julie K (2017) Sex-Dependent Intestinal Replication of an Enteric Virus. J Virol 91:
Franco, Luis H; Nair, Vidhya R; Scharn, Caitlyn R et al. (2017) The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense. Cell Host Microbe 22:421-423
Sumpter Jr, Rhea; Sirasanagandla, Shyam; Fernández, Álvaro F et al. (2016) Fanconi Anemia Proteins Function in Mitophagy and Immunity. Cell 165:867-81
Chen, Qiuyue; Denard, Bray; Lee, Ching-En et al. (2016) Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix. Mol Cell 63:567-578
Joslin, Stephanie N; Pybus, Christine; Labandeira-Rey, Maria et al. (2015) A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors. Infect Immun 83:146-60
Wei, Yongjie; An, Zhenyi; Zou, Zhongju et al. (2015) The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation. Elife 4:
Denard, Bray; Pavia-Jimenez, Andrea; Chen, Weina et al. (2015) Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome. PLoS One 10:e0129233
Robinson, Christopher M; Jesudhasan, Palmy R; Pfeiffer, Julie K (2014) Bacterial lipopolysaccharide binding enhances virion stability and promotes environmental fitness of an enteric virus. Cell Host Microbe 15:36-46

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