This amended competitive renewal application for continuation of a training program in musculoskeletal biology involves 18 training faculty at the University of Minnesota. The goals of this five-year renewal application are to: 1. Train 4 predoctoral fellows and 1 postdoctoral fellow for research careers as basic scientists or clinical investigators studying the causes, treatments, and response to therapy of musculoskeletal diseases. 2. Continue an educational environment for students, post-docs, post-doctoral fellows, and faculty encompassing a modern spectrum of research in musculoskeletal diseases, including basic discovery, investigation of musculoskeletal disease models, and study of clinical and translational outcomes of standard treatments. In the past five years, the University of Minnesota has invested considerable resources in the retention and recruitment of numerous talented, energetic and collaborative investigators interested in musculoskeletal biology. The training grant thus boasts a group of highly qualified research mentors in state-of-the-art research environments and provides an ideal modern setting for training and stimulating young research scientists. The research strengths of the institution are reflected in this application, which is divided into the areas of Musculoskeletal Cancer Biology and Therapeutics, Epidemiology and Clinical Outcomes, Osteoarthritis and Cartilage Biology, and Musculoskeletal Development. Support is requested for five positions (4 predoctoral and 1 postdoctoral) for each year. Predoctoral trainees eligible for this training program will be accepted into one of 14 existing degree or combined degree graduate programs that involve the training faculty. Postdoctoral fellows will be recruited by individual mentors and through the residency programs of the Dept. of Orthopaedic Surgery and the College of Veterinary Medicine. The training program will be integrated and enriched by a program of seminars, journal clubs and joint group meetings. The primary goals of the program are to attract exceptional young scientists in the field of musculoskeletal biology and to assist their intellectual and technical development into productive and independent investigators interested in the mechanisms and treatment of musculoskeletal diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR050938-10
Application #
8661116
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Panagis, James S
Project Start
2004-05-01
Project End
2015-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
10
Fiscal Year
2014
Total Cost
$137,727
Indirect Cost
$10,845
Name
University of Minnesota Twin Cities
Department
Orthopedics
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Lawrence, Rebekah L; Ellingson, Arin M; Ludewig, Paula M (2017) Validation of single-plane fluoroscopy and 2D/3D shape-matching for quantifying shoulder complex kinematics. Med Eng Phys :
Smeester, Branden A; Lee, Jang-Hern; Beitz, Alvin J (2017) Influence of social interaction on nociceptive-induced changes in locomotor activity in a mouse model of acute inflammatory pain: Use of novel thermal assays. Brain Res Bull 134:47-54
Lawrence, Rebekah L; Schlangen, Dustin M; Schneider, Katelyn A et al. (2017) Effect of glenohumeral elevation on subacromial supraspinatus compression risk during simulated reaching. J Orthop Res 35:2329-2337
Claeson, Amy A; Barocas, Victor H (2017) Planar biaxial extension of the lumbar facet capsular ligament reveals significant in-plane shear forces. J Mech Behav Biomed Mater 65:127-136
Aukes, Kelly; Forsman, Cynthia; Brady, Nicholas J et al. (2017) Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions. PLoS One 12:e0185736
Ellingson, Arin M; McGee, Corey; Nuckley, David J et al. (2017) Development, construct validity, and reproducibility of a mimetic sealed jar measuring the dynamics of opening. J Rehabil Assist Technol Eng 4:
Blixt, Nicholas C; Faulkner, Bora K; Astleford, Kristina et al. (2017) Class II and IV HDACs function as inhibitors of osteoclast differentiation. PLoS One 12:e0185441
Claeson, Amy A; Barocas, Victor H (2017) Computer simulation of lumbar flexion shows shear of the facet capsular ligament. Spine J 17:109-119
Ellingson, Arin M; Shaw, Miranda N; Giambini, Hugo et al. (2016) Comparative role of disc degeneration and ligament failure on functional mechanics of the lumbar spine. Comput Methods Biomech Biomed Engin 19:1009-18
Shuhaibar, Leia C; Egbert, Jeremy R; Edmund, Aaron B et al. (2016) Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone. Dev Biol 409:194-201

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