This application is for the continuation of the "Multidisciplinary Training in Cancer Research" program at Vanderbilt University (VU) initiated almost 20 years ago by Harold L. Moses. In this renewal application, the current P.I., Lynn M. Matrisian, proposes to change the name to "Microenvironmental Influences in Cancer" to reflect the enhanced focus of program faculty on the cellular and molecular biology underlying tumorhost interactions. The purpose of this training program is to prepare pre- and post-doctoral trainees for a career in basic and translational cancer research. The program supports predoctoral training of 6 Ph.D. or M.D./Ph.D. candidates and postdoctoral training of 3 Ph.D. or M.D. candidates/year. The Microenvironmental Influences in Cancer Training Program (MICTP) takes place in the backdrop of an active and growing Medical Center with state-of-the-art facilities, a vibrant NCIdesignated comprehensive cancer center, a basic science Department of Cancer Biology, an Interdisciplinary Graduate Program in Biomedical Sciences, an active Office of Postdoctoral Affairs, an effective Alliance with the neighboring minority-serving Meharry Medical College (MMC), and Graduate Programs in Cancer Biology at both VU and MMC. There is a comprehensive course in Cancer Biology, courses focusing on the tumor microenvironment, and abundant opportunities for extended learning and interactions through ongoing seminar series, retreats, and research-in-progress presentations. The postdoctoral training program consists primarily of laboratory research under the guidance of a faculty supervisor. The 27 preceptors include faculty from the VU departments of Cancer Biology, Cell &Dev. Biology, Pathology, Radiation Oncology, Surgery, and Medicine, and the Cancer Biology division of the Department of Biomedical Sciences at MMC. Although the emphasis is on basic and translational research, a special feature of this training grant is the requirement for exposure to clinical cancer research and care through rotations through medical and surgical clinics and tumor boards. This training program has been highly effective in selecting and advancing the careers of motivated and productive trainees in the field of cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009592-25
Application #
8267084
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1997-08-15
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
25
Fiscal Year
2012
Total Cost
$380,850
Indirect Cost
$25,097
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Scott, Sarah A; Spencer, Cierra T; O'Reilly, Matthew C et al. (2015) Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes. ACS Chem Biol 10:421-32
Krakowiak, M S; Noto, J M; Piazuelo, M B et al. (2015) Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene 34:1865-71
Chen, Jin; Song, Wenqiang; Amato, Katherine (2015) Eph receptor tyrosine kinases in cancer stem cells. Cytokine Growth Factor Rev 26:6-Jan
Andl, Thomas; Le Bras, Grégoire F; Richards, Nicole F et al. (2014) Concerted loss of TGF?-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma. Carcinogenesis 35:2602-10
Skrypnyk, Nataliya; Chen, Xiwu; Hu, Wen et al. (2014) PPAR* activation can help prevent and treat non-small cell lung cancer. Cancer Res 74:621-31
Andrews, Omozusi E; Cha, Diana J; Wei, Chunyao et al. (2014) RNAi-mediated gene silencing in zebrafish triggered by convergent transcription. Sci Rep 4:5222
Palmer, Trenis D; Martinez, Carlos H; Vasquez, Catalina et al. (2014) Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Cancer Res 74:173-87
Lindsey Jr, R Hunter; Pendleton, MaryJean; Ashley, Rachel E et al. (2014) Catalytic core of human topoisomerase II?: insights into enzyme-DNA interactions and drug mechanism. Biochemistry 53:6595-602
DeGraff, David J; Grabowska, Magdalena M; Case, Tom C et al. (2014) FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype. Lab Invest 94:726-39
Cleveland, Susan M; Goodings, Charnise; Tripathi, Rati M et al. (2014) LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp Hematol 42:581-93.e5

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