Abstract

What care is administered relies on what caregivers know and need to know. Lately, biomedical discoveries, advances in biomedical technology, and implementation research have shown an ability to identify the knowledge that is needed when it is needed, but how to put that knowledge in the hands of caregivers has been a challenge. The Institute of Medicine, has one way of dealing with this problem, it is called the a Learning Healthcare System. This proposal presents how one group, 31 site Childhood Absence Epilepsy Network (CAEN), intends to become an LHS. In this proposal we describe how three sites: Cincinnati Children's Hospital Medical Center, Denver Children's Hospital and Children's Hospital of Philadelphia have agreed to act as a pilot for implementing NIH sponsored i2b2 technology and developing novel software applications that include natural language processing to extend that technology. This initial collaboration is called the Multi-Institutional Pediatric Epilepsy Decision Support System (MiPeds - pronounced my peads)

Public Health Relevance

Electronic health records contain information that not only is essential for clinical care, but also provides a learning laboratory to increase the quality of care. We propose to extend the existing i2b2 technology by develop disease specific data marts and tools for pediatric epilepsy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Research Project (R01)
Project #
5R01LM011124-03
Application #
8514725
Study Section
Special Emphasis Panel (ZLM1-ZH-C (01))
Program Officer
Sim, Hua-Chuan
Project Start
2011-07-22
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$296,541
Indirect Cost
$54,951

  Institution

Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229

  Publications

Arya, Ravindra; Peariso, Katrina; Gaínza-Lein, Marina et al. (2018) Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus. Epilepsy Res 144:1-6
Abend, Nicholas S; Wagenman, Katherine L; Blake, Taylor P et al. (2015) Electrographic status epilepticus and neurobehavioral outcomes in critically ill children. Epilepsy Behav 49:238-44
Topjian, Alexis A; Fry, Michael; Jawad, Abbas F et al. (2015) Detection of electrographic seizures by critical care providers using color density spectral array after cardiac arrest is feasible. Pediatr Crit Care Med 16:461-7
Arya, Ravindra; Kothari, Harsh; Zhang, Zongjun et al. (2015) Efficacy of nonvenous medications for acute convulsive seizures: A network meta-analysis. Neurology 85:1859-68
Shinnar, Shlomo; Cnaan, Avital; Hu, Fengming et al. (2015) Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial. Neurology 85:1108-14
Jain, Sejal V; Horn, Paul S; Simakajornboon, Narong et al. (2015) Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study. Sleep Med 16:637-44
Dlugos, Dennis J (2015) The nature of neonatal status epilepticus--a clinician's perspective. Epilepsy Behav 49:88-9
Wirrell, Elaine C; Shellhaas, Renée A; Joshi, Charuta et al. (2015) How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium. Epilepsia 56:617-25
Wagenman, Katherine L; Blake, Taylor P; Sanchez, Sarah M et al. (2014) Electrographic status epilepticus and long-term outcome in critically ill children. Neurology 82:396-404
Sánchez Fernández, Iván; Abend, Nicholas S; Arndt, Daniel H et al. (2014) Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study. J Pediatr 164:339-46.e1-2

Showing the most recent 10 out of 17 publications