The Department of Surgery at Washington University School of Medicine (WUSM) is one of the nation's leading academic surgery departments, with a strong and uncompromising commitment to training the next generation of academic surgeon-scientists. The Surgical Oncology Basic Science and Translational Research Training Program is a critical component of this overall training goal. The current T32 application will provide surgical trainees from general surgery and other surgical subspecialties the opportunity to develop essential skill sets in basic science, translational, and public health research. The Surgical Oncology Research Training Program has evolved in parallel with a dynamic training environment at WUSM, and currently takes advantage of unique resources in the Department of Surgery, the Siteman Cancer Center, the Division of Biology and Biomedical Sciences, the Institute of Clinical and Translational Sciences, and the Department of Surgery's Division of Public Health Sciences to develop customized and highly structured formal didactic and mentored research experiences for individual surgical trainees. The success of the program is evidenced by the important research accomplishments made by trainees working with program faculty, and the long-term success of trainees in academic medicine. Of note, 5/8 trainees (63%) who have completed the research training program and their clinical training in the last ten years, and 35/60 trainees (58%) who have competed the program since its inception, remain in academic medicine, many with independent funding. Important changes to the Surgical Oncology Research Training Program in this competitive review include additions to the program leadership, development of two distinct research tracks (basic science track, and translational research/public health/clinical effectiveness track), and reduction in the number of training slots to allow for an increase in the tuition budget. These changes will ensure that the Surgical Oncology Research Training Program maintains excellence at the forefront of two different surgical oncology research paradigms, basic science research, and translational/public health/clinical effectiveness research. NCI support will allow WUSM to continue this highly successful research training program, providing the next generation of surgeon- scientists with the research training required to succeed in an increasingly competitive research environment.

Public Health Relevance

Surgeon-scientists are in a unique position to facilitate the clinical translation of basic science research discoveries, with the potential for significant improvements in patient care. The Surgical Oncology Basic Science and Translational Research Training Program will provide surgical trainees from general surgery and other surgical subspecialties the opportunity to develop essential skill sets in basic science, translational, and public health research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009621-29
Application #
9301485
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Perkins, Susan N
Project Start
1988-07-05
Project End
2019-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
29
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Cullinan, Darren R; Wise, Paul E; Delman, Keith A et al. (2018) Interim Analysis of a Prospective Multi-Institutional Study of Surgery Resident Experience with Flexibility in Surgical Training. J Am Coll Surg 226:425-431
Krasnick, Bradley A; Jin, Linda X; Davidson 4th, Jesse T et al. (2018) Adjuvant therapy is associated with improved survival after curative resection for hilar cholangiocarcinoma: A multi-institution analysis from the U.S. extrahepatic biliary malignancy consortium. J Surg Oncol 117:363-371
Nywening, Timothy M; Belt, Brian A; Cullinan, Darren R et al. (2018) Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma. Gut 67:1112-1123
Barron, Lauren; Courtney, Cathleen; Bao, James et al. (2018) Intestinal resection-associated metabolic syndrome. J Pediatr Surg 53:1142-1147
Meyer, Melissa A; Baer, John M; Knolhoff, Brett L et al. (2018) Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance. Nat Commun 9:1250
Sharma, Piyush K; Dmitriev, Igor P; Kashentseva, Elena A et al. (2018) Development of an adenovirus vector vaccine platform for targeting dendritic cells. Cancer Gene Ther 25:27-38
Ethun, Cecilia G; Lopez-Aguiar, Alexandra G; Anderson, Douglas J et al. (2018) Transplantation Versus Resection for Hilar Cholangiocarcinoma: An Argument for Shifting Treatment Paradigms for Resectable Disease. Ann Surg 267:797-805
Salles, Arghavan; Wright, Robert C; Milam, Laurel et al. (2018) Social Belonging as a Predictor of Surgical Resident Well-being and Attrition. J Surg Educ :
Chapman Jr, William C; Choi, Pamela; Hawkins, Alexander T et al. (2018) Benchmarking rectal cancer care: institutional compliance with a longitudinal checklist. J Surg Res 225:142-147
Hudson, Jessica L; Bell, Jennifer M; Crabtree, Traves D et al. (2018) Office-Based Spirometry: A New Model of Care in Preoperative Assessment for Low-Risk Lung Resections. Ann Thorac Surg 105:279-286

Showing the most recent 10 out of 179 publications