This proposal is for continuation of an interdisciplinary Cancer Cell Biology Training Program for predoctoral ludents at the University of North Carolina at Chapel Hill (UNC-CH). The premise of this program is that the doctoral students graduated by UNC-CH are well trained in the paradigms of molecular and cellular biology, but rarely do these students receive significant training in the pathobiology and treatment of cancer. With an increasing emphasis on translational, disease-oriented research, the need to address this deficiency in graduate student training has become of greater urgency. Thus, the broad goal of this program is to provide comprehensive training in cancer biology to allow students to effectively contribute to the new wave of translational research. The program provides a strong emphasis on the histopathology of cancer and the exposure of trainees to topics crucial to tumor biology, including angiogenesis, invasiveness, metastasis, cancer chemotherapy, and cancer drug discovery. Therefore, it fosters the training of doctoral candidates that are uniquely trained and clearly distinguished from those of individual departments or other training programs funded by the NIH at UNC-CH. This program is complemented by the excellence of the faculty at UNC-CH and the leadership and programs provided by the well-established Lineberger Comprehensive Cancer Center (LCCC). The 39 faculty preceptors are drawn from 10 different UNC-CH departments and three interdisciplinary predoctoral training curricula. Program preceptors are also members of the LCCC. A critical component of this training program is the establishment of a Cancer Cell Biology Curriculum that includes coursework developed specifically for the Program trainees that address key issues in cancer pathology, diagnosis, drug discovery and treatment. This predoctoral program is strongly complemented by the programs that have been developed for the LCCC's long-standing postdoctoral training program. Thus, together, these two training programs facilitate the LCCC's goal to create a comprehensive, interdisciplinary, cohesive and collaborative research environment to foster the development of both pre- and postdoctoral cancer researchers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA071341-15
Application #
7860724
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M1))
Program Officer
Myrick, Dorkina C
Project Start
1996-09-30
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
15
Fiscal Year
2010
Total Cost
$188,294
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pharmacology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Hayes, Tikvah K; Neel, Nicole F; Hu, Chaoxin et al. (2016) Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. Cancer Cell 29:75-89
Hughes, Robert M; Marvin, Christina M; Rodgers, Zachary L et al. (2016) Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents. Angew Chem Int Ed Engl 55:16080-16083
Serber, Daniel W; Runge, John S; Menon, Debashish U et al. (2016) The Mouse INO80 Chromatin-Remodeling Complex Is an Essential Meiotic Factor for Spermatogenesis. Biol Reprod 94:8
Ryan, Meagan B; Finn, Alexander J; Pedone, Katherine H et al. (2016) ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma. Mol Cancer Res 14:1009-1018
Runge, John S; Raab, Jesse R; Magnuson, Terry (2016) Epigenetic Regulation by ATP-Dependent Chromatin-Remodeling Enzymes: SNF-ing Out Crosstalk. Curr Top Dev Biol 117:1-13
Pattenden, Samantha G; Simon, Jeremy M; Wali, Aminah et al. (2016) High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility. Proc Natl Acad Sci U S A 113:3018-23
Giffin, Louise; West, John A; Damania, Blossom (2015) Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration. MBio 6:e01499-15
Karginova, Olga; Siegel, Marni B; Van Swearingen, Amanda E D et al. (2015) Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. Mol Cancer Ther 14:920-30
Karaca, Mehmet; Liu, Yuanbo; Zhang, Zhentao et al. (2015) Mutation of androgen receptor N-terminal phosphorylation site Tyr-267 leads to inhibition of nuclear translocation and DNA binding. PLoS One 10:e0126270
Ryan, Meagan B; Der, Channing J; Wang-Gillam, Andrea et al. (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1:183-198

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