OF TRAINING PROGRAM: Forsyth Institute proposes to offer a Postdoctoral Training Program in Oral and Craniofacial Research to health professionals and PhDs who are interested in further training in basic, clinical or patient-oriented oral health research. It also proposes to offer retraining in these areas to mid-career scientists. Specific training opportunities are available in Biofilms, Biomineralization and Biomimetics; Molecular Immunology and lnfectious Disease; Genomics and Oral Cancer; and Clinical Investigations. Linkage of projects between focus areas, especially between clinical investigations and other focus areas, will be encouraged. Mentors have outstanding records of published research consistent with the NIDCR mission, are well supported by NIH, and have appreciable experience in postdoctoral education. Collaborative, multidisciplinary and inter-professional interactions in academia and the biotechnology industry are characteristic of mentors' research. These multidisciplinary/collaborative research efforts of mentors serve as a base upon which the trainee can initiate similar collaborative research interactions. Mentored research is the cornerstone of the postdoctoral training experience. Enhancements to that experience will include a course in clinical research design, oral health targeted courses in immunology and infectious disease, and a course in ethical practices in scientific investigation. The program will also feature tutorials in research use of the Web, Bioinformatics, Genomics, and Grantsmanship, participation in the Forsyth/Harvard Seminar Series, Oral Biology colloquia, and departmental journal clubs, seminar/tutorials in career opportunities, and a postdoctoral research group (PRG). The PRG will be responsible for organizing an institutionally funded series of Postdoctoral Research Days in which international experts will be invited to speak formally and informally to the PRG. Leadership awareness and training will be facilitated by postdoctoral trainee mentoring of Boston high school, and dental and/or Forsyth dental hygiene students in summer research projects. A variety of strategies will be used to recruit trainees, including candidates from under-represented racial/ethnic groups who will be specifically encouraged. The goal is to provide training experiences that will prepare trainees to be principal investigators who can 1) successfully compete for research funds; 2) effectively communicate their ideas; 3) recognize the value of collaborative research interactions; 4) lead and inspire others to accomplish mutual research objectives; 5) translate their findings to practice; 6) become skilled in bioinformatic approaches; 7) make ethically correct decisions; and 8) be sensitive and harmonious in relationships with their peers.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZDE1-WG (02))
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Lipton, James A
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Forsyth Institute
United States
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Azuma, Mariane Maffei; Balani, Pooja; Boisvert, Heike et al. (2018) Endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis-induced inflammation in vitro. Biochem Biophys Res Commun 495:2383-2389
Ishii, Takenobu; Ruiz-Torruella, Montserrat; Ikeda, Atsushi et al. (2018) OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9. FASEB J 32:4016-4030
Kressirer, Christine A; Smith, Daniel J; King, William F et al. (2017) Scardovia wiggsiae and its potential role as a caries pathogen. J Oral Biosci 59:135-141
Hondroulis, Evangelia; Movila, Alexandru; Sabhachandani, Pooja et al. (2017) A droplet-merging platform for comparative functional analysis of m1 and m2 macrophages in response to e. coli-induced stimuli. Biotechnol Bioeng 114:705-709
Kanzaki, Hiroyuki; Movila, Alexandru; Kayal, Rayyan et al. (2017) Phosphoglycerol dihydroceramide, a distinctive ceramide produced by Porphyromonas gingivalis, promotes RANKL-induced osteoclastogenesis by acting on non-muscle myosin II-A (Myh9), an osteoclast cell fusion regulatory factor. Biochim Biophys Acta Mol Cell Biol Lipids 1862:452-462
Wisitrasameewong, W; Kajiya, M; Movila, A et al. (2017) DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption. J Dent Res 96:685-693
Yamaguchi, Tsuguno; Movila, Alexandru; Kataoka, Shinsuke et al. (2016) Proinflammatory M1 Macrophages Inhibit RANKL-Induced Osteoclastogenesis. Infect Immun 84:2802-12
Rothman, Gabriel R; Blackiston, Douglas J; Levin, Michael (2016) Color and intensity discrimination in Xenopus laevis tadpoles. Anim Cogn 19:911-9
Movila, Alexandru; Mawardi, Hani; Nishimura, Kazuaki et al. (2016) Possible pathogenic engagement of soluble Semaphorin 4D produced by ??T cells in medication-related osteonecrosis of the jaw (MRONJ). Biochem Biophys Res Commun 480:42-47
Wollenberg, Amanda C; Jagdish, Tanush; Slough, Greg et al. (2016) Death Becomes Them: Bacterial Community Dynamics and Stilbene Antibiotic Production in Cadavers of Galleria mellonella Killed by Heterorhabditis and Photorhabdus spp. Appl Environ Microbiol 82:5824-37

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