? This revised application is for support of four training positions in an established program in digestive diseases at the University of California, San Francisco. Its focus is mucosal biology and clinical research in luminal gastroenterology and pancreas; training in hepatology is a separate program. The mentor group comprises 9 members of the UCSF Division of Gastroenterology and 8 investigators from affiliated Departments and programs who are actively involved in collaborative research with faculty of the Gl Division. All have independent research programs and a record of successful mentoring. The training environment is broadly interdisciplinary, reflecting the involvement of Gl Division faculty in the graduate program for Biomedical Sciences, the Immunology Program, and the Cancer Center. Changes to the Program since the 1999 competing renewal application include: (1) Creation of a comprehensive program in inflammatory bowel diseases, the UCSF Center for Colitis and Crohn's Disease, which encompasses fundamental, translational and clinical research as well as state-of-the-art clinical care; (2) implementation of a program in cancer of the pancreas and another for cancer risk assessment, focused mainly on colon cancer; and (3) a K30 award to the UCSF Department of Epidemiology and Biostatistics, to expand its didactic program in clinical research methods with a Master's degree in Clinical Research. In the year since the initial submission of this renewal proposal, a program in outcomes and health services research has been formally constituted under the direction of John Inadomi, MD. Also, the School of Medicine received an institutional K12 award for training of both fellows and junior faculty in translational research. Subspecialty fellows selected for support under this training grant generally will hold an MD or MD/PhD and will have completed both a program in Internal Medicine and 12 months of intensive training in clinical gastroenterology. Highly qualified PhD recipients, whose research is focused on the Gl tract and has translational potential, also may apply. The duration of research training is three years, except for fellows with exceptionally strong prior experience who may do two years only. Program graduates will have a well-defined research focus and the tools needed for success with a career in biomedical investigation in the field of gastroenterology. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007007-32A1
Application #
7122597
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1975-07-01
Project End
2011-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
32
Fiscal Year
2006
Total Cost
$162,611
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Kattah, Michael G; Shao, Ling; Rosli, Yenny Y et al. (2018) A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. J Exp Med 215:1839-1852
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Onizawa, Michio; Oshima, Shigeru; Schulze-Topphoff, Ulf et al. (2015) Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol 16:785
Jensen, Christopher D; Doubeni, Chyke A; Quinn, Virginia P et al. (2015) Adjusting for patient demographics has minimal effects on rates of adenoma detection in a large, community-based setting. Clin Gastroenterol Hepatol 13:739-46
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