This is a request for the seventh consecutive renewal of a T-32 award for training postdoctoral candidates in research to prepare them for leadership roles in academic gastroenterology. TRAINING RECORD: Over the last ten years, a total of 19 trainees have completed training: 14/19 trainees pursued a research oriented career after training and six trainees have received NIH funding. One minority and seven women candidates have graduated from this program. ADMINISTRATION: Dr. Arun Sanyal, a senior funded investigator and the director of the division of Gastroenterology at VCU Medical Center, is the director of the T-32 program. He is supported by the executive committee that advises him and helps execute the training program, and a steering committee that evaluates the overall direction of the program. PROGRAM ORGANIZATION: There are four major participating units: (1) Enteric neuro-muscular and epithelial biology, (2) Hepatobiliary lipids, (3) Gl Cancer and (4) Splanchnic and hepatic blood flow groups. There are a total of 23 participating faculty who are all independently funded with annual research base (directs costs) of $15.5 million. Over the last ten years, the faculty have published 957 medline [sic]-indexed papers;the average impact factor of papers published by members of the division of gastroenterology is 12.42. There are extensive collaborative networks between the faculty members who also frequently co-mentor trainees. TRAINEES: This program accepts trainees who are either board eligible in internal medicine (66-75% of trainees) and/or have a PhD in a biomedical field (25-33% of trainees). Special efforts are made annually to recruit minority candidates. TRAINING PROGRAMS: Trainess [sic] will have the opportunity to train in one of the participating unit laboratories. Each unit has been structured to be seamlessly integrated with institutional core facilities so that translational research can be performed at the highest level. A comprehensive training program that includes didactic lectures, research seminars, technology seminars, journal clubs, cell biology courses and hands on training in research is provided. Mandatory training in research integrity and grant writing are also provided. Each trainee is under the direct supervision of one mentor sometimes with additional content comentors. The need for research training, the strong record of this program and continued research strengths of this prgroam [sic] form a basis for this application for renewal of this T-32 training grant.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
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Budget End
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Virginia Commonwealth University
Internal Medicine/Medicine
Schools of Medicine
United States
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Stewart, Karen E; Haller, Deborah L; Sargeant, Carol et al. (2015) Readiness for behaviour change in non-alcoholic fatty liver disease: implications for multidisciplinary care models. Liver Int 35:936-43
Stewart, Karen E; Hart, Robert P; Gibson, Douglas P et al. (2014) Illness apprehension, depression, anxiety, and quality of life in liver transplant candidates: implications for psychosocial interventions. Psychosomatics 55:650-8
Patidar, Kavish R; Sydnor, Malcolm; Sanyal, Arun J (2014) Transjugular intrahepatic portosystemic shunt. Clin Liver Dis 18:853-76
Satapathy, Sanjaya K; Sanyal, Arun J (2014) Nonendoscopic management strategies for acute esophagogastric variceal bleeding. Gastroenterol Clin North Am 43:819-33
Aleman, Jose O; Eusebi, Leonardo H; Ricciardiello, Luigi et al. (2014) Mechanisms of obesity-induced gastrointestinal neoplasia. Gastroenterology 146:357-73
Min, Hae-Ki; Sookoian, Silvia; Pirola, Carlos J et al. (2014) Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells. Am J Physiol Gastrointest Liver Physiol 307:G66-76
Bhogal, Harjit K; Sanyal, Arun J (2013) The molecular pathogenesis of cholestasis in sepsis. Front Biosci (Elite Ed) 5:87-96
Ridlon, Jason M; Hylemon, Phillip B (2012) Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7?-dehydroxylating intestinal bacterium. J Lipid Res 53:66-76
Nguyen, Tuyet A T; Sanyal, Arun J (2012) Pathophysiology guided treatment of nonalcoholic steatohepatitis. J Gastroenterol Hepatol 27 Suppl 2:58-64
Bhogal, Harjit K; Sanyal, Arun J (2011) Using transjugular intrahepatic portosystemic shunts for complications of cirrhosis. Clin Gastroenterol Hepatol 9:936-46; quiz e123

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