The goal of the Childhood Diabetes Clinical &Molecular Research Training Program (CDCMRT) is to train MD pediatric endocrinology fellows and PhD fellows for academic research careers in type 2 diabetes, insulin resistance, obesity and fitness in children. Insulin resistance, usually associated with obesity and increasingly leading to overt diabetes, has become a major health problem in children. Research fellows in this program have the opportunity to begin a career in molecular and cellular research in internationally recognized laboratories engaged in biochemical and molecular genetic studies of pancreatic islet biology, insulin sensitivity, or whole body pathophysiology studying human metabolism, energy expenditure, adiposity, fitness, androgen excess and the metabolic syndrome in ethnically diverse children and adolescents. Objectives include 1) establishment of a high quality and productive research project, 2) development of a progressive record of publication in respected research journals, 3) application for and procurement of extramural grant funding during fellowship, and 4) pursuit of academic careers in childhood diabetes, insulin resistance and obesity research by a minimum of 50% of the graduates of this program. To achieve these objectives, a curriculum has been developed in collaboration with the NIH-funded University of Wisconsin Institute for Clinical and Translational Research Program (ICTR) to provide training in diabetes and insulin resistance, research techniques, statistics and study design, medical ethics, scientific writing and presentation skills, and preparation of grant applications. CDCMRT research opportunities involve clinical, translational, and basic science activities that have been both independently and collaboratively successful and are directed towards the study of diabetes and insulin resistance diseases. The continually rising burden of diabetes and other obesity-related metabolic disorders, the strong record of accomplishment of our first group of T32-supported fellows and recognition of a national shortage of basic science researchers and pediatric endocrinologists with childhood obesity and type 2 diabetes training prompt us to seek continued funding for the CDCMRT program. The University of Wisconsin Center for the Study of Diversity in Health Care will assist the CDCMRT in recruiting under-represented minority trainee candidates. Given the opportunity, the CDCMRT program will continue to provide trainees with a comprehensive mentored research training experience that will prepare them for innovative, productive research careers in childhood diabetes, insulin resistance and obesity.

Public Health Relevance

Insulin resistance, usually associated with obesity and increasingly causing type 2 diabetes, has become a major health problem in children. The mission of the training program is to train MD pediatric endocrinology fellows or PhD fellows for academic research careers in type 2 diabetes, insulin resistance, obesity and fitness in children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK077586-06A1
Application #
8664579
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
2007-07-01
Project End
2019-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
6
Fiscal Year
2014
Total Cost
$127,627
Indirect Cost
$9,434
Name
University of Wisconsin Madison
Department
Pediatrics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Pollock, Allison J; Allen, David B; Wiebe, Donald et al. (2016) Development of filter paper hemoglobin A1c assay applicable to newborn screening. Clin Chim Acta 457:24-6
Pollock, Allison J; Seibert, Tasa S; Salvatori, Cristiana et al. (2016) Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome. Horm Res Paediatr :
Pollock, Allison J; Seibert, Tasa; Allen, David B (2016) Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth. J Pediatr 173:232-4
Pollock, Allison J; Moreno, Megan A; Bekx, M Tracy et al. (2016) Online Resources for Pediatric Type 1 Diabetes: What Adolescents Want. J Diabetes Sci Technol 10:1419-1420
Rehm, Jennifer L; Wolfgram, Peter M; Hernando, Diego et al. (2015) Proton density fat-fraction is an accurate biomarker of hepatic steatosis in adolescent girls and young women. Eur Radiol 25:2921-30
Wolfgram, Peter M; Allen, David B (2015) Factors influencing growth effects of inhaled corticosteroids in children. J Allergy Clin Immunol 136:1711-2.e1-2
Wolfgram, Peter M; Connor, Ellen L; Rehm, Jennifer L et al. (2015) In Nonobese Girls, Waist Circumference as a Predictor of Insulin Resistance Is Comparable to MRI Fat Measures and Superior to BMI. Horm Res Paediatr 84:258-65
Pollock, Allison J; Hitt, Stacy L; Stier, Michael A et al. (2015) Eosinophilic Endomyocarditis: A Rare Case of Neonatal Mortality. AJP Rep 5:e150-2
Pollock, Allison J; Fost, Norman; Allen, David B (2015) Growth attenuation therapy: practice and perspectives of paediatric endocrinologists. Arch Dis Child 100:1185
Seibert, Tasa S; Allen, David B; Carrel, Aaron L (2014) Adolescent Obesity and Its Risks: How to Screen and When to Refer. J Clin Outcomes Manag 21:87-96

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