In 2007, The University of Chicago launched the graduate program in Biophysical Sciences (BPHYS) designed to provide interdisciplinary training at the interface between the physical and biological sciences and promote the University's interdisciplinary research culture.
Aim 1. Establish a nationally-recognized graduate program that will train leaders and pioneers in interdisciplinary exploration.
Aim 2. Promote collaborative research at the interface between the physical and biological sciences as a route to discovery and innovation.
Aim 3. Enhance the culture of The University of Chicago via an interdisciplinary graduate training program that brings together scientific leaders in the scientific community.
Aim 4. Develop and validate an approach to predoctoral training that is individual, student focused, and interdisciplinary and collaborative throughout. In pursuit of these broad aims, several innovative strategies have been incorporated along with many standard elements of a cohesive training program. Ultimately, the engine that will drive program excellence will be a cadre of talented trainees and committed mentors working together to pursue the highest quality science. Innovations: Sophisticated Curriculum. The first year curriculum is built around an intense, year-long practical lab course that teaches the students how to conduct collaborative science and produce, measure &analyze biomolecules using modern biophysical methods. A full-time Curriculum Director is responsible for this practical course and for integrating it with didactic course work, which includes established courses from diverse departments as well as new interdisciplinary courses offered by the Program. Dual Mentorship. Beginning in the second year, each student is a full participant in two active research groups from different scientific fields. For some, this arrangement may simply yield an opportunity to cross fields and become deeply interdisciplinary scientists. Others will initiate new fields of research.

Public Health Relevance

The University of Chicago conducts research in physics, chemistry and biology but in separate departments. This grant supports a new interdepartmental graduate program The primary goal is to train students to apply methods from chemistry and physics to the study of biological and health-related problems

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZEB1-OSR-E (J1))
Program Officer
Baird, Richard A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
Schools of Medicine
United States
Zip Code
Hong, Lu; Vani, Bodhi P; Thiede, Erik H et al. (2018) Molecular dynamics simulations of nucleotide release from the circadian clock protein KaiC reveal atomic-resolution functional insights. Proc Natl Acad Sci U S A 115:E11475-E11484
Krause, Matthew D; Huang, Ru-Ting; Wu, David et al. (2018) Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics. Proc Natl Acad Sci U S A 115:E11349-E11358
Riback, Joshua A; Bowman, Micayla A; Zmyslowski, Adam et al. (2018) Response to Comment on ""Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water"". Science 361:
Zhao, Yunlong; Harrison, Devin L; Song, Yuran et al. (2018) Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep 24:379-390.e6
Leypunskiy, Eugene; K?c?man, Emre; Shah, Mili et al. (2018) Geographically Resolved Rhythms in Twitter Use Reveal Social Pressures on Daily Activity Patterns. Curr Biol 28:3763-3775.e5
Neilson, Julia W; Califf, Katy; Cardona, Cesar et al. (2017) Significant Impacts of Increasing Aridity on the Arid Soil Microbiome. mSystems 2:
Stam, Samantha; Freedman, Simon L; Banerjee, Shiladitya et al. (2017) Filament rigidity and connectivity tune the deformation modes of active biopolymer networks. Proc Natl Acad Sci U S A 114:E10037-E10045
Sohail, Sara H; Dahlberg, Peter D; Allodi, Marco A et al. (2017) Communication: Broad manifold of excitonic states in light-harvesting complex 1 promotes efficient unidirectional energy transfer in vivo. J Chem Phys 147:131101
Tietjen, Gregory T; Baylon, Javier L; Kerr, Daniel et al. (2017) Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1. Biophys J 113:1505-1519
Riback, Joshua A; Katanski, Christopher D; Kear-Scott, Jamie L et al. (2017) Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response. Cell 168:1028-1040.e19

Showing the most recent 10 out of 86 publications