The University of Pennsylvania Medical Scientist Training Program provides support for both MD-PhD and VMD-PhD trainees and is currently in its 37th year of funding. The primary goal of the program is to identify, train and mentor a diverse group of outstanding men and women who will become the leaders of biomedical human and veterinary research, as well as teachers and scholars. To accomplish this goal, we have established flexible training plans that emphasize the integration of the professional and research degrees in preparation for careers that will make use of both. The large institutional commitment to this goal is reflected by the investment that the medical and veterinary schools have made in this program, providing it with resources that are used to help cover tuition and stipend costs, maintain enrichment activities, and support administration of the program. There are currently 220 combined degree students (185 MD-PhD and 25 VMD-PhD), all of whom are fully funded. Admission is open to recent college graduates and to current Penn MD, VMD and PhD students. Selection emphasizes academic excellence, research experience, creativity, letters of recommendation and a well-articulated plan for a career in research. Most trainees do graduate work in the biomedical sciences, but 17% are currently taking advantage of the breadth of opportunities offered by a large university by enrolling in graduate programs in Biomedical Engineering, Physics, Health Care Economics, History &Sociology of Science, Medical Anthropology, Urban Design, and Epidemiology. The proposed training faculty reflects this diversity of interests. It includes 147 senior and junior PhD, MD-PhD and MD investigators in departments, centers and institutes spread across Penn's campus. As of June 2011, there have been 442 MD-PhD and 63 VMD-PhD graduates since program inception. 76% of MD-PhD alumni and 87% of VMD-PhD alumni who have completed postgraduate training are employed by academic centers, research institutes, the biotech and pharmaceutical industries or federal agencies. Many have NIH or other extramural funding for their research. The average time to completion for recent graduates in both programs has been 8 years. The attrition rate for the past 10 years has been low: 4% in the MD-PhD program and 8% in the VMD-PhD program. Specific goals for the next 5 years include 1) continued growth to achieve at least 200 MD-PhD and 30 VMD-PhD students, 2) expanded partnerships with additional graduate programs at Penn, 3) further integration of the graduate and professional degrees, 4) reducing time to degree without compromising training, and 5) attracting and training a diverse group of individuals who will be prepared for the discovery and application of new knowledge through basic, translational and patient-oriented research.

Public Health Relevance

As the pace at which biomedical research advances increases, there is a greater need than ever for physicians and veterinarians who are trained investigators, working at the intersection between medicine and science. The goal of the Medical Scientist Training Program at the University of Pennsylvania is to identify, train and mentor a diverse group of outstanding men and women and to help them become teachers, scholars, and leaders of biomedical research that is relevant to the full spectrum of human and animal disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Preusch, Peter
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University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
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Lo, Agnes S; Mao, Xuming; Mukherjee, Eric M et al. (2016) Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris. PLoS One 11:e0156800
Guggisberg, Ann M; Sundararaman, Sesh A; Lanaspa, Miguel et al. (2016) Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin. J Infect Dis 214:1085-91
Busch, Johanna I; Unger, Travis L; Jain, Nimansha et al. (2016) Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes. Hum Mol Genet 25:2681-2697
Molleston, Jerome M; Sabin, Leah R; Moy, Ryan H et al. (2016) A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Genes Dev 30:1658-70
Finkelman, Brian S; French, Benjamin; Bershaw, Luanne et al. (2016) Predicting prolonged dose titration in patients starting warfarin. Pharmacoepidemiol Drug Saf 25:1228-1235
Bengsch, Bertram; Johnson, Andy L; Kurachi, Makoto et al. (2016) Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Immunity 45:358-73
Kalbasi, Anusha; Komar, Chad; Tooker, Graham M et al. (2016) Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma. Clin Cancer Res :
Hinderer, Christian; Bell, Peter; Louboutin, Jean-Pierre et al. (2016) Neonatal tolerance induction enables accurate evaluation of gene therapy for MPS I in a canine model. Mol Genet Metab 119:124-30
van Ingen, Gijs; Li, Jin; Goedegebure, André et al. (2016) Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene. Nat Commun 7:12792
Nirschl, Jeffrey J; Magiera, Maria M; Lazarus, Jacob E et al. (2016) α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep 14:2637-52

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