Continued support is requested for an ongoing program of graduate research training in molecular biology and biophysics at the University of Oregon. This training activity is centered in the Institute of Molecular Biology, and also involves additional groups with related scientific interests. Funds are requested for 12 predoctoral positions, within a program that includes approximately 59 graduate students, 47 postdoctoral trainees, and 22 training faculty. The program places special emphasis on the control of gene expression and nucleic acid structure/function, molecular basis of signaling and cell function, protein structure and dynamics, and molecular approaches to development and differentiation. The basic aspect of the training is laboratory research carried out under the direction of a facult member in the molecular biology and biophysics training program. Through this experience, the trainee becomes skilled at posing questions about fundamental biological processes and designing experiments to answer those questions. The training is augmented by formal courses offered by the Biology, Chemistry, and Physics Departments, by seminar programs that highlight current research in molecular biology, biophysics, and related disciplines, by the close involvement of a Thesis Advisory Committee, and by research seminar and journal club presentations by trainees. The training facilities include the laboratories of the faculty and support services such as the structural biology biophysical facility, the state-of-the-art genomics and imaging facilities, and a large number of other modern facilities. Major equipment is shared and housed in common space. The laboratories of most of the faculty are contiguous and in interconnected buildings. This arrangement fosters strong interdisciplinary interactions and collaborations among faculty and students.

Public Health Relevance

This proposal is to provide support for graduate training leading to the Ph.D. degree in molecular biology and biophysics. Our goal is to produce creative, intellectually critical, and experimentally skilled bioscientists. We believe that trainig towards this end is first and foremost accomplished at the laboratory bench, and training is focused on learning to find a rigorous experimental answer to a significant scientific question. The training program actively promotes strongly interdisciplinary and collaborative science. We want our students to develop into imaginative and capable research scientists, equipped with the knowledge to lead research programs of their own, thereby strengthening the national resource in this area.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TR))
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Oregon
Organized Research Units
United States
Zip Code
Wheeler, Lucas C; Lim, Shion A; Marqusee, Susan et al. (2016) The thermostability and specificity of ancient proteins. Curr Opin Struct Biol 38:37-43
Wheeler, Lucas C; Donor, Micah T; Prell, James S et al. (2016) Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family. PLoS One 11:e0164740
Zoschke, Reimo; Watkins, Kenneth P; Miranda, Rafael G et al. (2016) The PPR-SMR protein PPR53 enhances the stability and translation of specific chloroplast RNAs in maize. Plant J 85:594-606
Anderson, Dave W; McKeown, Alesia N; Thornton, Joseph W (2015) Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites. Elife 4:e07864
Anderson, Jeneva K; Huang, Julie Y; Wreden, Christopher et al. (2015) Chemorepulsion from the Quorum Signal Autoinducer-2 Promotes Helicobacter pylori Biofilm Dispersal. MBio 6:e00379
Bailey, Matthew J; Prehoda, Kenneth E (2015) Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs. Dev Cell 35:199-210
Blanco-Sánchez, Bernardo; Clément, Aurélie; Fierro Jr, Javier et al. (2014) Complexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis. Dis Model Mech 7:547-59
Ward, W Luke; Plakos, Kory; DeRose, Victoria J (2014) Nucleic acid catalysis: metals, nucleobases, and other cofactors. Chem Rev 114:4318-42
McKeown, Alesia N; Bridgham, Jamie T; Anderson, Dave W et al. (2014) Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module. Cell 159:58-68
Osborn, Maire F; White, Jonathan D; Haley, Michael M et al. (2014) Platinum-RNA modifications following drug treatment in S. cerevisiae identified by click chemistry and enzymatic mapping. ACS Chem Biol 9:2404-11

Showing the most recent 10 out of 79 publications