The Cell and Molecular Biology (CMB) Training Program at the University of Texas Southwestern Medical Center at Dallas fosters the development of Ph.D. scientists with the skills and resources necessary to succeed as independent researchers in a rapidly changing scientific environment. In response to this changing environment, the CMB Training Program at UT Southwestern is largely driven by the trainees. The program focuses on Cellular and Molecular Biology as it applies to medical advances, reflecting the research interests of the students and the laboratories in which they train. It provides formal training in statistical analysis of biological data and emphasizes the importance of collaborative research in acquiring the breadth of knowledge and skills needed for the rapid pace of developments. The program offers unique small group settings for the trainees to acquire new knowledge, form scientific hypotheses, and critically analyze data. Students compete for positions in this training program by writing a research summary and personal statement about why they would like to participate. The application process is open to students in their second year of a Ph.D. program or in their first or second graduate school year of the MSTP program. The new trainees are chosen by the CMB Steering Committee. Most students remain in the training program for up to 3 years, usually including one year of advanced didactic training and up to 2 years of independent research. Currently, there are 14 granted slots, with 13 funded due to budget constraints of the NIH. We believe that the growth of our student population, along with the strength of our program within the biomedical research community, justifies a modest increase in the number of positions funded, although we are well aware of the limited resources available. The interdisciplinary, student-focused CMB program is structured to stimulate the trainees'critical thinking and to present novel opportunities to question and evaluate cellular and molecular research important for human health. Scientists equipped with these skills will make discoveries that increase quality and years of healthy life, one of the overall goals of the Department of Health and Human Service's Healthy People 2010 Report. Faculty members in the CMB program are involved in basic research relating to many of the Healthy People 2010 focus areas.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008203-24
Application #
8101044
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1987-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
24
Fiscal Year
2011
Total Cost
$405,444
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Pharmacology
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Zhou, Xiaorong; Updegraff, Barrett L; Guo, Yabin et al. (2017) PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis. Cancer Res 77:187-197
Horvath, Patricia M; Kavalali, Ege T; Monteggia, Lisa M (2017) CRISPR/Cas9 system-mediated impairment of synaptobrevin/VAMP function in postmitotic hippocampal neurons. J Neurosci Methods 278:57-64
Hepler, Chelsea; Shao, Mengle; Xia, Jonathan Y et al. (2017) Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice. Elife 6:
Liu, Shuzhen; Liu, Hua; Johnston, Andrea et al. (2017) MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis. Proc Natl Acad Sci U S A 114:E7450-E7459
Hepler, Chelsea; Vishvanath, Lavanya; Gupta, Rana K (2017) Sorting out adipocyte precursors and their role in physiology and disease. Genes Dev 31:127-140
Topalovski, Mary; Hagopian, Michelle; Wang, Miao et al. (2016) Hypoxia and Transforming Growth Factor ? Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer. J Biol Chem 291:22244-22252
Young, Jonathan H; Peyton, Michael; Seok Kim, Hyun et al. (2016) Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer. Bioinformatics 32:1373-9
Collins 3rd, James J; Wendt, George R; Iyer, Harini et al. (2016) Stem cell progeny contribute to the schistosome host-parasite interface. Elife 5:e12473
Vishvanath, Lavanya; MacPherson, Karen A; Hepler, Chelsea et al. (2016) Pdgfr?+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. Cell Metab 23:350-9
Topalovski, Mary; Brekken, Rolf A (2016) Matrix control of pancreatic cancer: New insights into fibronectin signaling. Cancer Lett 381:252-8

Showing the most recent 10 out of 100 publications