The objective of this Chemistry-Biology Interface (CBI) Predoctoral Program is to provide cross-disciplinary training to talented students with diverse interests that will enable them to apply the mechanistic and atomistic perspective of chemistry to important biological problems. The program brings together outstanding faculty trainers from six academic units at the University of Delaware that represent diverse disciplines of organic chemistry, bioinorganic chemistry, analytical chemistry, biochemistry, structural biology, molecular biology, cell biology, systems biology/bioinformatics, molecular biology, cell biology, plant biology, virology, and developmental biology. The faculty trainers represent promising new investigators and established researchers with vibrant research programs in biomolecular science and experience in training graduate students. Trainees with diverse undergraduate educational backgrounds are selected on the basis of their interests in interdisciplinary science, their GRE scores, undergraduate GPA and letters of recommendation. Trainees are admitted through existing graduate programs of Chemistry &Biochemistry, Chemical Engineering or Biological sciences. Trainees will satisfy the degree requirements for their specific departmental program in addition to the requirements for the CBI program. Five one semester courses (15credits) will be selected from a diverse list of course offerings from six departments. A key feature of the program will be three laboratory rotations to provide them with hands-on experience in the different disciplines. Between courses and laboratory rotations students are expected to have exposure to concepts and methods from the atomistic to the cellular. A course on scientific integrity and the responsible conduct of research is also required. A weekly seminar series will provide trainees opportunities to present their own work, learn from both faculty trainers and outside speakers. Trainees will undertake an intensive independent research experience culminating in a dissertation representing an original contribution to a field at the chemistry-biology interface. This program follows a successful model for training scientists with both broad scientific knowledge as well as solid foundations in a chosen core discipline.
Advances in molecular medicine are often impeded by traditional training paradigms in which chemists and biologists often do not speak the same scientific language nor understand advances in each other's fields. This program provides trainees opportunities to learn to share ideas across traditionally separate fields in order to fertilize new ideas and innovations that require working knowledge of both chemistry and biology.
|Smith, Natalee J; Rohlfing, Katarina; Sawicki, Lisa A et al. (2018) Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones. Org Biomol Chem 16:2164-2169|
|DeMeester, Kristen E; Liang, Hai; Jensen, Matthew R et al. (2018) Synthesis of Functionalized N-Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis. J Am Chem Soc 140:9458-9465|
|Drake, Walter R; Hou, Ching-Wen; Zachara, Natasha E et al. (2018) New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT. J Bioenerg Biomembr 50:231-240|
|Lu, Manman; Sarkar, Sucharita; Wang, Mingzhang et al. (2018) 19F Magic Angle Spinning NMR Spectroscopy and Density Functional Theory Calculations of Fluorosubstituted Tryptophans: Integrating Experiment and Theory for Accurate Determination of Chemical Shift Tensors. J Phys Chem B 122:6148-6155|
|Liu, Jun; Chen, Qingqing; Rozovsky, Sharon (2018) Selenocysteine-Mediated Expressed Protein Ligation of SELENOM. Methods Mol Biol 1661:265-283|
|Franke, Karl R; Schmidt, Skye A; Park, Sunhee et al. (2018) Analysis of Brachypodium miRNA targets: evidence for diverse control during stress and conservation in bioenergy crops. BMC Genomics 19:547|
|Lauro, Mackenzie L; D'Ambrosio, Elizabeth A; Bahnson, Brian J et al. (2017) Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2. ACS Infect Dis 3:264-270|
|Long, Christopher P; Gonzalez, Jacqueline E; Cipolla, Robert M et al. (2017) Metabolism of the fast-growing bacterium Vibrio natriegens elucidated by 13C metabolic flux analysis. Metab Eng 44:191-197|
|Liu, Jun; Chen, Qingqing; Rozovsky, Sharon (2017) Utilizing Selenocysteine for Expressed Protein Ligation and Bioconjugations. J Am Chem Soc 139:3430-3437|
|McNeely, Patrick M; Naranjo, Andrea N; Forsten-Williams, Kimberly et al. (2017) A2AR Binding Kinetics in the Ligand Depletion Regime. SLAS Discov 22:166-175|
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