The objective of this Chemistry-Biology Interface (CBI) Predoctoral Program is to provide cross-disciplinary training to talented students with diverse interests that will enable them to apply the mechanistic and atomistic perspective of chemistry to important biological problems. The program brings together outstanding faculty trainers from six academic units at the University of Delaware that represent diverse disciplines of organic chemistry, bioinorganic chemistry, analytical chemistry, biochemistry, structural biology, molecular biology, cell biology, systems biology/bioinformatics, molecular biology, cell biology, plant biology, virology, and developmental biology. The faculty trainers represent promising new investigators and established researchers with vibrant research programs in biomolecular science and experience in training graduate students. Trainees with diverse undergraduate educational backgrounds are selected on the basis of their interests in interdisciplinary science, their GRE scores, undergraduate GPA and letters of recommendation. Trainees are admitted through existing graduate programs of Chemistry &Biochemistry, Chemical Engineering or Biological sciences. Trainees will satisfy the degree requirements for their specific departmental program in addition to the requirements for the CBI program. Five one semester courses (15credits) will be selected from a diverse list of course offerings from six departments. A key feature of the program will be three laboratory rotations to provide them with hands-on experience in the different disciplines. Between courses and laboratory rotations students are expected to have exposure to concepts and methods from the atomistic to the cellular. A course on scientific integrity and the responsible conduct of research is also required. A weekly seminar series will provide trainees opportunities to present their own work, learn from both faculty trainers and outside speakers. Trainees will undertake an intensive independent research experience culminating in a dissertation representing an original contribution to a field at the chemistry-biology interface. This program follows a successful model for training scientists with both broad scientific knowledge as well as solid foundations in a chosen core discipline.
Advances in molecular medicine are often impeded by traditional training paradigms in which chemists and biologists often do not speak the same scientific language nor understand advances in each other's fields. This program provides trainees opportunities to learn to share ideas across traditionally separate fields in order to fertilize new ideas and innovations that require working knowledge of both chemistry and biology.
|McNeely, Patrick M; Naranjo, Andrea N; Forsten-Williams, Kimberly et al. (2017) A2AR Binding Kinetics in the Ligand Depletion Regime. SLAS Discov 22:166-175|
|Chiu, Josephine; Valente, Kristin N; Levy, Nicholas E et al. (2017) Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations. Biotechnol Bioeng 114:1006-1015|
|Schaefer, Amy K; Melnyk, James E; Baksh, Michael M et al. (2017) Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2. ACS Chem Biol 12:2216-2224|
|Lauro, Mackenzie L; D'Ambrosio, Elizabeth A; Bahnson, Brian J et al. (2017) Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2. ACS Infect Dis 3:264-270|
|Liang, Hai; DeMeester, Kristen E; Hou, Ching-Wen et al. (2017) Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications. Nat Commun 8:15015|
|Schaefer, Amy K; Wastyk, Hannah C; Mohanan, Vishnu et al. (2017) Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70. Biochemistry 56:4445-4448|
|Hou, Ching-Wen; Lauro, Mackenzie L; Leimkuhler Grimes, Catherine (2016) Redefining the Defensive Line: Critical Components of the Innate Immune System. ACS Infect Dis 2:746-748|
|Kharkar, Prathamesh M; Rehmann, Matthew S; Skeens, Kelsi M et al. (2016) Thiol-ene click hydrogels for therapeutic delivery. ACS Biomater Sci Eng 2:165-179|
|Yao, Mengyin; Elling, Felix J; Jones, CarriAyne et al. (2016) Heterotrophic bacteria from an extremely phosphate-poor lake have conditionally reduced phosphorus demand and utilize diverse sources of phosphorus. Environ Microbiol 18:656-67|
|Panish, Robert A; Chintala, Srinivasa R; Fox, Joseph M (2016) A Mixed-Ligand Chiral Rhodium(II) Catalyst Enables the Enantioselective Total Synthesis of Piperarborenine?B. Angew Chem Int Ed Engl 55:4983-7|
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