The University of Michigan proposes to continue a predoctoral Chemistry-Biology Interface (CBI) Training Program for a selected group of Ph.D. students. The number of students requested for this new training program is 10 for a five-year period of support. The participating units are the Department of Chemistry, College of Literature, Science, and the Arts;the Departments of Biological Chemistry and Pharmacology, Medical School;the Biophysics Research Division (BRD);the Chemical Biology Ph.D. (CB IDP) program and he Department of Medicinal Chemistry, College of Pharmacy. The faculty of the CBI Training Program includes synthetic organic and inorganic chemists, bioorganic chemists, bioanalytical chemists, protein chemists, mechanistic enzymologists, spectroscopists, and crystallographers. The Ph.D. degrees will be awarded in Chemistry, Biological Chemistry, Chemical Biology, Pharmacology, and Medicinal Chemistry. Students will be appointed to the training grant for two years beginning in the second year of their Ph.D. program. The curriculum of the Training Program includes a novel student sabbatical to be completed before graduation and, preferably, while the trainee is supported by the training grant. In an effort to enhance interaction between students and provide more opportunity for trainees to present their research, we have instituted a monthly luncheon that is attended by present and past CBI trainees. Twice per year, students from the larger CB IDP in order to foster interactions between students of both programs. In addition, seminars and individual meetings with CBI trainees have been implemented in order to provide career counseling. Two core courses in Chemical Biology and regularly scheduled opportunities for the trainees to present their research results to the Training Program Faculty and fellow trainees are also integral to the program. Research opportunities for the trainees are varied and involve faculty with a wide range of expertise in research at the interface of chemistry and biology. The trainees have access to the most sophisticated techniques and instrumentation in modern research at this interface. The faculty of the Training Program has a long history of collaborative research and this interactive approach to research is a central theme in the training of a new generation of scientists in these four basic disciplines. During the next five years, the CBI Program is positioned to be a major contributor to the new interdisciplinary Life Sciences Initiative at the University of Michigan.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Fabian, Miles
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University of Michigan Ann Arbor
Schools of Arts and Sciences
Ann Arbor
United States
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Rogawski, David S; Grembecka, Jolanta; Cierpicki, Tomasz (2016) H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development. Future Med Chem 8:1589-607
Dugan, Amanda; Majmudar, Chinmay Y; Pricer, Rachel et al. (2016) Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture. J Am Chem Soc 138:12629-35
Yang, Pei; Homan, Kristoff T; Li, Yaoxin et al. (2016) Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-Gβ1γ2 Complex. Biochemistry 55:2841-8
Dugan, Amanda; Pricer, Rachel; Katz, Micah et al. (2016) TRIC: Capturing the direct cellular targets of promoter-bound transcriptional activators. Protein Sci 25:1371-7
Gantt, Sister M Lucy; Decroos, Christophe; Lee, Matthew S et al. (2016) General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry 55:820-32
Horowitz, Scott; Koepnick, Brian; Martin, Raoul et al. (2016) Determining crystal structures through crowdsourcing and coursework. Nat Commun 7:12549
Waldschmidt, Helen V; Homan, Kristoff T; Cruz-Rodríguez, Osvaldo et al. (2016) Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem 59:3793-807
Kaplan, Will; Khatri, Hem Raj; Nagorny, Pavel (2016) Concise Enantioselective Total Synthesis of Cardiotonic Steroids 19-Hydroxysarmentogenin and Trewianin Aglycone. J Am Chem Soc 138:7194-8
Rogawski, David S; Ndoj, Juliano; Cho, Hyo Je et al. (2015) Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. Biochemistry 54:5401-13
Kwarcinski, Frank E; Steffey, Michael E; Fox, Christel C et al. (2015) Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment Elaboration. ACS Med Chem Lett 6:898-901

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