The field of developmental biology has matured in recent years, largely through the integration of many disciplines within biological sciences, including genetics, cell biology, embryology, physiology, molecular biology, biochemistry, and evolutionary biology. The focus for developmental biology at the University of Minnesota is provided by the Developmental Biology Center, which is based in the Department of Genetics, Cell Biology, and Development - an all-University department within both the School of Medicine and the College of Biological Sciences. The Developmental Biology Center embraces members from many other departments within the University including Neuroscience, Pediatrics, Plant Biology, Laboratory Medicine, and Mathematics. The Developmental Biology Center organizes a popular annual University of Minnesota Developmental Biology Symposium, runs a weekly and monthly series of research seminars in developmental biology, where graduate students and postdoctoral researchers present their work, and promotes interactions and collaborations among developmental biologists at the University of Minnesota. The trainers are all members of the Center and work in diverse areas of developmental biology using many different model organisms, including mice, zebrafish, Xenopus, Drosophila, C. elegans, Dictyostelium, and Arabidopsis. The principal graduate program for developmental biology trainees is the Molecular, Cellular, Developmental Biology, and Genetics (MCDB&G) graduate program. This program is built around strong core graduate courses in laboratory techniques, molecular biology, genetics, cell biology, developmental biology, literature analysis, and laboratory rotations in diverse systems. The trainers have strong research programs and strong records of commitment to graduate and postdoctoral training. Five predoctoral trainees will be chosen for training grant support, largely from the pool of graduate students in MCDB&G but possibly also from other graduate programs, such as Neuroscience and Biochemistry, Molecular Biology and Biophysics. Trainees will be supported for one to three years, after they have begun their thesis work in the laboratories of the trainers. The training laboratories and core facilities are all well equipped. An understanding of development is fundamental to much of modern medicine and will ultimately contribute key insights into the causes of, and possible therapies for, many major public health problems ranging from congenital birth defects to senescence.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
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Pediatrics Subcommittee (CHHD)
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Mukhopadhyay, Mahua
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Edelman, Theresa L B; McCulloch, Katherine A; Barr, Angela et al. (2016) Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing. G3 (Bethesda) 6:4077-4086
Ferrell, Patrick I; Hexum, Melinda K; Kopher, Ross A et al. (2014) Functional assessment of hematopoietic niche cells derived from human embryonic stem cells. Stem Cells Dev 23:1355-63
McCulloch, Katherine A; Rougvie, Ann E (2014) Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression. Proc Natl Acad Sci U S A 111:15450-5
Ran, Dan; Shia, Wei-Jong; Lo, Miao-Chia et al. (2013) RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood 121:2882-90
Zheng, Li; Saunders, Cosmo A; Sorensen, Erika B et al. (2013) Notch signaling from the endosome requires a conserved dileucine motif. Mol Biol Cell 24:297-307
Kang, Yuan-Lin; Yochem, John; Bell, Leslie et al. (2013) Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Mol Biol Cell 24:308-18
Berkseth, Matt; Ikegami, Kohta; Arur, Swathi et al. (2013) TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination. Proc Natl Acad Sci U S A 110:16033-8
Krentz, Anthony D; Murphy, Mark W; Zhang, Teng et al. (2013) Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol 377:67-78
Bluske, Krista K; Vue, Tou Yia; Kawakami, Yasuhiko et al. (2012) ?-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development 139:2692-702
Arur, Swathi; Ohmachi, Mitsue; Berkseth, Matt et al. (2011) MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex-determination module. Dev Cell 20:677-88

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