Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA049695-05
Application #
2093385
Study Section
Biochemistry Study Section (BIO)
Project Start
1990-04-01
Project End
1997-03-31
Budget Start
1994-04-01
Budget End
1997-03-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Rutgers University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Gosslau, Alexander; Jao, David Li-En; Butler, Renee et al. (2009) Thermal killing of human colon cancer cells is associated with the loss of eukaryotic initiation factor 5A. J Cell Physiol 219:485-93
Chatterjee, Ishita; Gross, Stephane R; Kinzy, Terri Goss et al. (2006) Rapid depletion of mutant eukaryotic initiation factor 5A at restrictive temperature reveals connections to actin cytoskeleton and cell cycle progression. Mol Genet Genomics 275:264-76
Jao, David Li-En; Chen, Kuang Yu (2006) Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex. J Cell Biochem 97:583-98
Xu, Aiguo; Jao, David Li-En; Chen, Kuang Yu (2004) Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display. Biochem J 384:585-90
Li-En Jao, David; Yu Chen, Kuang (2002) Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging. J Cell Biochem 86:590-600
Xu, A; Chen, K Y (2001) Hypusine is required for a sequence-specific interaction of eukaryotic initiation factor 5A with postsystematic evolution of ligands by exponential enrichment RNA. J Biol Chem 276:2555-61
Lu, J; Chen, Z P; Yan, Y P et al. (2000) Aminohexanoic hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells. Cancer Lett 160:59-66
Matuoka, K; Chen, K Y (2000) Possible role of subunit A of nuclear factor Y (NF-YA) in normal human diploid fibroblasts during senescence. Biogerontology 1:261-71
Matuoka, K; Yu Chen, K (1999) Nuclear factor Y (NF-Y) and cellular senescence. Exp Cell Res 253:365-71
Chen, Z P; Chen, K Y (1997) Dramatic attenuation of hypusine formation on eukaryotic initiation factor 5A during senescence of IMR-90 human diploid fibroblasts. J Cell Physiol 170:248-54

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