Cardiovascular disease continues to be a dominant cause of morbidity and mortality in the United States and throughout much of the world. Advances that have been made in recent decades have come from the dedication and talents of many researchers working at the basic science level up through to clinical translation including population and care delivery studies. Over the past 35 years, The Johns Hopkins T32 Program in Cardiovascular Disease has trained many of these researchers, and with this renewal proposal we aim to continue this success. Our philosophy is to provide a broad-based, multi- and inter-disciplinary research environment with which to train post-doctoral fellows in basic, translational, clinical, and/or population science. Our program accepts physicians in Cardiology, some with PhDs as well, who are dedicated to pursuing an academic research career, and non-clinical fellows (PhD or MD) who are pursuing cardiovascular research. This mixture of basic and clinical scientists has fostered an unusual environment conducive to out-of-the-box thinking and translation of novel approaches to new understandings and treatment of cardiovascular disease. Most mentors have their primary appointments in the Division of Cardiology, but our faculty also include members from Pulmonary Medicine, Radiology, Institutes of Genetic Medicine and Cell Engineering, Biomedical Engineering, Pediatric Cardiology, Pathology, Epidemiology, and The Welch Center of Clinical Research. All of the faculty have long- standing histories of collaborations. Ten primary areas of research are covered: basic science in ventricular and vascular pathobiology, molecular biology and genetics, proteomics, cardiovascular imaging and computational modeling, epidemiology, risk assessment, genome-wide association research, preventive medicine strategies, clinical/translational studies in electrophysiology, coronary disease, and heart failure, and cardiovascular aging. The program supports 12 positions (our last renewal was approved for 13 positions) for 2 years of un-interrupted research training. It also includes a position with a 3rd structured year of formal course work to provide a masters degree in clinical investigation. With this renewal, we continue our primary goal of providing leadership in academic cardiology, training future leaders in all levels of research to help combat cardiovascular disease.

Public Health Relevance

Heart and vascular disease is a leading cause of disability and death in the United States. The Johns Hopkins Cardiology Post-doctoral Training Program, now in its 35th consecutive year, provides broad multi-disciplinary training spanning from basic science up through to population/outcomes research. Our goal is to train the next generation of academic cardiovascular research leaders to continue the important work of tackling these important and common diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007227-37
Application #
8240024
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
1981-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
37
Fiscal Year
2012
Total Cost
$791,473
Indirect Cost
$60,590
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Martin, Seth S; Khokhar, Arif A; May, Heidi T et al. (2015) HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: the Lipoprotein Investigators Collaborative. Eur Heart J 36:22-30
Sharma, Kavita; Kass, David A (2014) Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies. Circ Res 115:79-96
Chow, Grant V; Silverman, Michael G; Tunin, Richard S et al. (2014) Efficacy of cardiac resynchronization in acutely infarcted canine hearts with electromechanical dyssynchrony. Heart Rhythm 11:1819-26
Silverman, Michael G; Blaha, Michael J; Krumholz, Harlan M et al. (2014) Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis. Eur Heart J 35:2232-41
Kirk, Jonathan A; Holewinski, Ronald J; Kooij, Viola et al. (2014) Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3*. J Clin Invest 124:129-38
Amin, Nivee P; Martin, Seth S; Blaha, Michael J et al. (2014) Headed in the right direction but at risk for miscalculation: a critical appraisal of the 2013 ACC/AHA risk assessment guidelines. J Am Coll Cardiol 63:2789-94
Voros, Szilard; Rinehart, Sarah; Vazquez-Figueroa, Jesus G et al. (2014) Prospective, head-to-head comparison of quantitative coronary angiography, quantitative computed tomography angiography, and intravascular ultrasound for the prediction of hemodynamic significance in intermediate and severe lesions, using fractional flow Am J Cardiol 113:23-9
Silverman, Michael G; Harkness, James R; Blankstein, Ron et al. (2014) Baseline subclinical atherosclerosis burden and distribution are associated with frequency and mode of future coronary revascularization: multi-ethnic study of atherosclerosis. JACC Cardiovasc Imaging 7:476-86
Kirk, Jonathan A; Kass, David A (2013) Electromechanical dyssynchrony and resynchronization of the failing heart. Circ Res 113:765-76
Sibley, Christopher T; Vavere, Andrea L; Gottlieb, Ilan et al. (2013) MRI-measured regression of carotid atherosclerosis induced by statins with and without niacin in a randomised controlled trial: the NIA plaque study. Heart 99:1675-80

Showing the most recent 10 out of 101 publications