This Competing Continuation Application for a well-established Ruth L. Kirschstein Institutional National Research Service Award (T32) is focused on the postdoctoral training of M.D., M.D.-Ph.D., and Ph.D. candidates to prepare them to pursue independent careers as successful Clinician-Scientists and/or Biomedical Research Scientists, whose primary interest is the cellular and molecular mechanisms of human disease. Its primary training goal is the development of core research competencies through both informal and structured didactic exercises, coupled with an in-depth mentored research experience, in a nurturing and supportive academic medical center environment. The programmatic emphasis is on understanding the basic pathogenetic mechanisms underlying major disease processes that affect the cardiovascular, pulmonary, hematopoietic and immune systems, through the application of the multidisciplinary research tools and strategies of modern cellular and molecular biology, immunology, genetics and genomics, integrative physiology and bioinformatics. The current Training Program, sponsored by the National Heart, Lung and Blood Institute, has been in continuous existence since 1958, and is based in the Department of Pathology at the Brigham and Women's Hospital, a primary teaching affiliate of Harvard Medical School. While the Training Program's Core Faculty is comprised primarily of clinician-scientists and basic biomedical researchers in the Department of Pathology, trainees also are encouraged to avail themselves of a wide spectrum of opportunities afforded by research mentors/laboratories in Harvard-affiliated research/medical center institutions (e.g., The Immune Diseases Institute - formerly the Center for Blood Research, the Broad Institute, Children's Hospital Boston, Massachusetts General Hospital, Massachusetts Institute of Technology and Dana-Farber Cancer Institute). Trainees are selected from a national pool of applicants, via a proactive recruitment process, and the Program's emphasis is on tailoring a research training experience to fit a given candidate's background, scientific interests and career goals. The overarching scientific principle is one of translational molecular pathology - the probing of disease mechanisms at a fundamental mechanistic level that yields new insights that point the way to targeted treatments for diseases, and, ultimately, their prevention.

Public Health Relevance

Diseases of the cardiovascular system (e.g., heart attacks and strokes), as well as disorders of the blood and immune systems (e.g., autoimmune disorders) represent a major health burden. Equipped with the skills of modern molecular pathology, new researchers can learn to probe the basic mechanisms of these diverse diseases and then translate this knowledge into novel and effective treatments and preventative measures.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007627-29
Application #
8479394
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1985-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
29
Fiscal Year
2013
Total Cost
$733,947
Indirect Cost
$54,033
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Venkatesh, Deepak; Mruk, Dolores; Herter, Jan M et al. (2016) AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function. Am J Pathol 186:270-84
Bucci, Vanni; Tzen, Belinda; Li, Ning et al. (2016) MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses. Genome Biol 17:121
Zimmerman, Brandon; Kelly, Brendan; McMillan, Brian J et al. (2016) Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell 167:1041-1051.e11
Watanabe, Rei; Gehad, Ahmed; Yang, Chao et al. (2015) Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci Transl Med 7:279ra39
Rosetti, Florencia; Chen, Yunfeng; Sen, Mehmet et al. (2015) A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. Cell Rep :
Herter, Jan M; Grabie, Nir; Cullere, Xavier et al. (2015) AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun 6:10182
Patterson, Heide Christine; Gerbeth, Carolin; Thiru, Prathapan et al. (2015) A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling. Proc Natl Acad Sci U S A 112:E5679-88
Guerra-Moreno, Angel; Isasa, Marta; Bhanu, Meera K et al. (2015) Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response. J Biol Chem 290:29695-706
Alekseyenko, Artyom A; Walsh, Erica M; Wang, Xin et al. (2015) The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes Dev 29:1507-23
Huynh, Alexandria; DuPage, Michel; Priyadharshini, Bhavana et al. (2015) Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol 16:188-96

Showing the most recent 10 out of 111 publications