This proposal represents a revised competitive renewal application for support of research training in cardiovascular science at the University of Minnesota.
The aim of this proposal is to provide rigorous research training in cardiovascular science to prepare candidates for a career in academic cardiology or cardiovascular investigation. A comprehensive curriculum has been developed, including formal course work, as well as an intensive laboratory experience, to provide a firm foundation in the concepts and methodology of cardiovascular research. The training program has been designed to provide a multidisciplinary research experience crossing traditional disciplines to emphasize application of unique research methodology to problems of clinical importance in cardiovascular science. The proposal has been revised in response to the previous critique to respond to specific questions raised by the reviewers and to update the proposal with additional institutional commitments that further enhance the training program. In addition to research training, special attention is paid to providing instruction in written and oral presentation of laboratory data, preparation of research grants, and development of mentoring skills. MD candidates who have begun their training in clinical cardiology or who elect to perform a 3-year period of research prior to beginning their clinical cardiology training, as well as postdoctoral PhD candidates will be accepted for a 2-3 year period of intensive research training. Training opportunities have been developed in four academic theme areas: (1) cardiac development and regeneration from stem cell populations;(2) molecular and integrative cardiovascular physiology;(3) cardiovascular applications of nuclear magnetic resonance, and (4) clinical and epidemiologic studies leading to a Master of Science degree in clinical research. These specific academic themes were chosen on the basis of four considerations;(1) they are areas of current research interest in which the potential for great strides in knowledge and understanding exist;(2) they are areas in which there is demand for trained investigators and academic physicians;(3) they are areas in which there is significant depth of research expertise and facilities with stable funding to provide a comprehensive training program at the University of Minnesota, and (4) they are areas in which interdisciplinary relationships already exist, thus ensuring trainee involvement in a multidisciplinary collaborative research experience. The long- term goal of this program is to provide a continuing stream of physician scientists and basic investigators working in cardiovascular science who are trained to use state-of-the-art technology to explore important research topics and successfully compete for independent grant funding.
|Kwon, Younghoon; Misialek, Jeffrey R; Duprez, Daniel et al. (2017) Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: the MESA study. Europace 19:1759-1766|
|Kwon, Younghoon; Kazaglis, Louis; Cho, Yeilim et al. (2017) Test-Retest Reliability of Two Consecutive Mean Sleep Latency Tests in Patients with Hypersomnia. Sleep Biol Rhythms 15:337-339|
|Kwon, Younghoon; Koene, Ryan J; Kwon, Osung et al. (2017) Effect of Sleep-Disordered Breathing on Appropriate Implantable Cardioverter-Defibrillator Therapy in Patients With Heart Failure: A Systematic Review and Meta-Analysis. Circ Arrhythm Electrophysiol 10:e004609|
|Rebbeck, Robyn T; Nitu, Florentin R; Rohde, David et al. (2016) S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex. J Biol Chem 291:15896-907|
|Prins, Kurt W; Asp, Michelle L; Zhang, Huiliang et al. (2016) Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice. JACC Basic Transl Sci 1:122-130|
|Wang, Huan; Hou, Lei; Kwak, Dongmin et al. (2016) Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression. Hypertension 68:114-22|
|Wang, Huan; Kwak, Dongmin; Fassett, John et al. (2016) CD28/B7 Deficiency Attenuates Systolic Overload-Induced Congestive Heart Failure, Myocardial and Pulmonary Inflammation, and Activated T Cell Accumulation in the Heart and Lungs. Hypertension 68:688-96|
|Kwon, Younghoon; Norby, Faye L; Jensen, Paul N et al. (2016) Association of Smoking, Alcohol, and Obesity with Cardiovascular Death and Ischemic Stroke in Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study and Cardiovascular Health Study (CHS). PLoS One 11:e0147065|
|Kwon, Younghoon; Van't Hof, Jeremy; Roy, Samit S et al. (2016) A Novel Method for Assessing Cardiac Output With the Use of Oxygen Circulation Time. J Card Fail 22:921-924|
|Gomez-Hurtado, Nieves; Boczek, Nicole J; Kryshtal, Dmytro O et al. (2016) Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol 9:|
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