This proposal represents a revised new submission for support of research training in cardiovascular science at the University of Minnesota.
The aim of this proposal is to provide rigorous research training in cardiovascular science to prepare candidates for a career in academic cardiology or in cardiovascular investigation. Comprehensive curricula have been developed, including formal coursework as well as an intensive laboratory experience, to provide a firm foundation in the concepts and methodology of cardiovascular research. Special attention is paid to providing instruction in written and oral presentation of laboratory data, preparation of research grants, and development of mentoring skills. M.D. candidates who have completed their training in clinical cardiology in part or in full, as well as postdoctoral Ph.D. candidates will be accepted for a two to three year period of intensive research training. Training opportunities have been developed in four academic theme areas: (1) Cardiovascular applications of nuclear magnetic resonance; (2) molecular and integrative cardiovascular physiology; (3) stem cell biology, and (4) clinical and epidemiologic studies leading to a Master of Science degree in Clinical Research. These specific academic themes were chosen on the basis of four considerations: (1) they are areas of current research interest in which potential for great strides in knowledge and understanding exist; (2) they are areas in which there is demand for trained investigators and academic physicians; (3) they are areas in which there is sufficient depth of research expertise and facilities in laboratories with stable funding to provide a comprehensive training program at the University of Minnesota, and (4) they are areas in which interdisciplinary relationships already exist, thus ensuring trainee involvement in multidisciplinary collaborative research. The long-term goal of this program is to provide a continuing stream of basic cardiovascular scientists and physician investigators who are trained to use state-of-the-art technology to explore important research topics and successfully compete for grant funding.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL069764-02
Application #
6755075
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Schucker, Beth
Project Start
2003-07-01
Project End
2008-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
2
Fiscal Year
2004
Total Cost
$373,926
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Kwon, Younghoon; Jacobs Jr, David R; Lutsey, Pamela L et al. (2018) ""Sleep disordered breathing and ECG R-wave to radial artery pulse delay, The Multi-Ethnic Study of Atherosclerosis"". Sleep Med 48:172-179
Kwon, Younghoon; Misialek, Jeffrey R; Duprez, Daniel et al. (2017) Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: the MESA study. Europace 19:1759-1766
Wang, Huan; Kwak, Dongmin; Fassett, John et al. (2017) Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy. Basic Res Cardiol 112:25
Kwon, Younghoon; Kazaglis, Louis; Cho, Yeilim et al. (2017) Test-Retest Reliability of Two Consecutive Mean Sleep Latency Tests in Patients with Hypersomnia. Sleep Biol Rhythms 15:337-339
Kwon, Younghoon; Koene, Ryan J; Kwon, Osung et al. (2017) Effect of Sleep-Disordered Breathing on Appropriate Implantable Cardioverter-Defibrillator Therapy in Patients With Heart Failure: A Systematic Review and Meta-Analysis. Circ Arrhythm Electrophysiol 10:e004609
Rebbeck, Robyn T; Nitu, Florentin R; Rohde, David et al. (2016) S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine ReceptorĀ·Calmodulin Complex. J Biol Chem 291:15896-907
Gomez-Hurtado, Nieves; Boczek, Nicole J; Kryshtal, Dmytro O et al. (2016) Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol 9:
Prins, Kurt W; Asp, Michelle L; Zhang, Huiliang et al. (2016) Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice. JACC Basic Transl Sci 1:122-130
Wang, Huan; Hou, Lei; Kwak, Dongmin et al. (2016) Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression. Hypertension 68:114-22
Wang, Huan; Kwak, Dongmin; Fassett, John et al. (2016) CD28/B7 Deficiency Attenuates Systolic Overload-Induced Congestive Heart Failure, Myocardial and Pulmonary Inflammation, and Activated T Cell Accumulation in the Heart and Lungs. Hypertension 68:688-96

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