Proposed herein is a training program - Lipid Signaling and Functional Lipidomics in Cardiovascular and Respiratory Diseases (LCRD) - for MD/PhD students and postdoctoral fellows at Virginia Commonwealth University (VCU) School of Medicine. The LCRD training program is an outgrowth of VCU's long history of innovative cardiovascular research combined with our strength in lipid metabolism, signaling, and functional lipidomics. New scientists are needed in the area of lipid signaling and functions in heart, respiratory, and cardiovascular disorders because future success in prevention and treatment of these increasingly important human diseases will require sophisticated understanding of the molecular and cellular mechanisms involved and the use of molecular biology, genomic and bioinformatics technology, as well as the new technology of lipidomics/metabolomics. The goal of the program is to provide exceptional interdisciplinary training in preparation for careers as independent investigators dedicated to biomedical research in heart, lung, and blood disorders. This interdepartmental training program is directed individually by highly qualified research advisors, including several MD and MD/PhD mentors who serve as outstanding role models, and overall by a program steering committee, which has two members who ran highly successful longstanding MD/PhD programs. Hence, LCRD trainees will benefit from an extended network of mentors, including members of their individual trainee advisory committees and the LCRD Steering Committee. Training includes rigorous laboratory research, seminars, advanced courses, biweekly LCRD Colloquium, and annual LCRD Research Retreat. A major strength is the quality of the research programs of the 22 well-funded program faculty members from five departments who have productive, energetic, and collaborative research efforts in many areas of relevant to thematic focus of this program. Trainees benefit from vigorous faculty involvement, experiences in communication of their work, and excellent core facilities, including state of the art lipidomics/metabolomics, all of which provide a superb environment for training the next generations of cardiovascular and pulmonary investigators who will make basic biomedical discoveries and translate them into better patient outcomes.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL094290-05
Application #
8426144
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
2009-05-01
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
5
Fiscal Year
2013
Total Cost
$274,668
Indirect Cost
$18,611
Name
Virginia Commonwealth University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Oyeniran, Clement; Sturgill, Jamie L; Hait, Nitai C et al. (2015) Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. J Allergy Clin Immunol 136:1035-46.e6
Newton, Jason; Lima, Santiago; Maceyka, Michael et al. (2015) Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy. Exp Cell Res 333:195-200
Kim, Eugene Y; Sturgill, Jamie L; Hait, Nitai C et al. (2014) Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. FASEB J 28:4347-58
Lima, Santiago; Milstien, Sheldon; Spiegel, Sarah (2014) A real-time high-throughput fluorescence assay for sphingosine kinases. J Lipid Res 55:1525-30
Wijesinghe, Dayanjan S; Brentnall, Matthew; Mietla, Jennifer A et al. (2014) Ceramide kinase is required for a normal eicosanoid response and the subsequent orderly migration of fibroblasts. J Lipid Res 55:1298-309
Liang, Jie; Nagahashi, Masayuki; Kim, Eugene Y et al. (2013) Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 23:107-20
Lima, Santiago; Spiegel, Sarah (2013) Sphingosine kinase: a closer look at last. Structure 21:690-2
Nagahashi, Masayuki; Kim, Eugene Y; Yamada, Akimitsu et al. (2013) Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB J 27:1001-11
Mietla, Jennifer A; Wijesinghe, Dayanjan S; Hoeferlin, L Alexis et al. (2013) Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase. J Lipid Res 54:1834-47
Vanhille, Derek L; Hill, Lori D; Hilliard, Dashaunda D et al. (2013) A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk. Mol Genet Genomic Med 1:98-107

Showing the most recent 10 out of 18 publications