The Brown CardioPulmonary Training Program has as its overall objective the training of physicians and scientists who will become independent investigators in the molecular basis and pathobiology of cardiovascular and pulmonary diseases and the outcomes of prevention and treatment of these diseases. This will be accomplished by a rigorous program of didactic training and mentored research experience in a collaborative, multidisciplinary setting with career development training. Four postdoctoral trainees with an MD, PhD, or MD/PhD degree will be accepted per year into a 3- year research training program. Thirty-three experienced and well-funded faculty trainers plus seven promising junior faculty trainers from 11 academic departments have developed a Training Program that utilizes resources from 7 Brown teaching hospitals plus Brown University. The Training Program aims to bridge gaps between bio-medical, behavioral and public health disciplines to advance knowledge regarding how best to reduce disease burden among patients with diseases that affect the cardiovascular system and lungs. This will be accomplished by training in Molecular Pathobiology of Cardiovascular and Pulmonary Diseases or in Health Services/Outcomes. This Training Program is uniquely positioned to train individuals in research related to diseases that involve these systems, such as aging. Having trainees looking at these problems from both bench to bedside and bedside to practice aspects can lead to new insights, lines of synergistic research and advances in science using both molecular methods and epidemiologic, clinical trials, and health services investigations.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-R (O2))
Program Officer
Roltsch, Mark
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Rhode Island Hospital
United States
Zip Code
Potz, Brittany A; Sabe, Ashraf A; Elmadhun, Nassrene Y et al. (2017) Calpain inhibition modulates glycogen synthase kinase 3? pathways in ischemic myocardium: A proteomic and mechanistic analysis. J Thorac Cardiovasc Surg 153:342-357
Potz, Brittany A; Sabe, Ashraf A; Elmadhun, Nassrene Y et al. (2017) Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia. Surgery 161:1394-1404
Liang, Olin D; So, Eui-Young; Egan, Pamela C et al. (2017) Endothelial to haematopoietic transition contributes to pulmonary arterial hypertension. Cardiovasc Res 113:1560-1573
Scrimgeour, Laura A; Potz, Brittany A; Elmadhun, Nassrene Y et al. (2017) Alcohol attenuates myocardial ischemic injury. Surgery 162:680-687
Wu, Keith Q; Muratore, Christopher S; So, Eui-Young et al. (2017) M1 Macrophage-Induced Endothelial-to-Mesenchymal Transition Promotes Infantile Hemangioma Regression. Am J Pathol 187:2102-2111
Feng, Jun; Liu, Yuhong; Sabe, Ashraf A et al. (2016) Differential impairment of adherens-junction expression/phosphorylation after cardioplegia in diabetic versus non-diabetic patients. Eur J Cardiothorac Surg 49:937-43
Koo, Patrick; McCool, F Dennis; Hale, Lauren et al. (2016) Association of obstructive sleep apnea risk factors with nocturnal enuresis in postmenopausal women. Menopause 23:175-82
Sabe, Ashraf A; Potz, Brittany A; Elmadhun, Nassrene Y et al. (2016) Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia. J Thorac Cardiovasc Surg 151:245-52
Cooper, Leroy L; Woodard, Todd; Sigurdsson, Sigurdur et al. (2016) Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory. Hypertension 67:176-82
Potz, Brittany A; Sabe, Ashraf A; Abid, M Ruhul et al. (2016) Calpains and Coronary Vascular Disease. Circ J 80:4-10

Showing the most recent 10 out of 66 publications