This T32 application for a postdoctoral fellowship program in cardiovascular outcomes research is designed to meet a regional and national need for more scholars in cardiovascular outcomes and quality of care research by extending and improving an existing AHA-funded outcomes research training program that is unique in the Midwest. This Mid America Heart Institute / University of Missouri-Kansas City research program provides a robust foundation with which young investigators can acquire the techniques of cardiovascular outcomes and quality of care research. As such, it has grown to be the central unifying research program in our region of 2 medical schools and 4 hospital systems and serves as a specialized training experience for more distant programs, including Washington University in St. Louis and the University of Iowa. Our objective is to recruit and mentor outstanding potential researchers who are motivated to learn and apply outcomes research principles and techniques in performing comparative effectiveness research and translating existing knowledge to clinical practice. The 2-year training program is comprised of 3 synergistic components: 1) a basic foundation of general skills for clinical research (including a Masters degree in clinical research), 2) specialized skills for outcomes research and academic 'survival skills'(our outcomes-based core curriculum), and 3) hands-on research. Courses are highly interactive and provide fellows opportunities to actively work with the concepts being studied. Hallmarks of the research experiences include multi- disciplinary group mentorship, individualized to meet the needs of each trainee, access to numerous existing data sources, and highly experienced statistical support. Enhancements planned for the existing program include adding training opportunities within Kansas City;creating new opportunities to do external research rotations at Yale University to support exposure to the use of CMS data;enhancing the current strength of the training program's use of secondary data to include a greater emphasis on primary data collection for small pilot projects;and extending mentorship support beyond the 2-year, focused training program. Administering the program will be a qualified program director, supported by an experienced associate and assistant director. Leaders in 7 methodological cores (large database analysis, economics and decision analysis, qualitative and implementation research, study design methodology and statistics and community-based participatory research) are committed to supporting the training program. The program will be supported by internal and external advisory committees. Collectively, our committed team will provide a formal training, mentorship and evaluation program with highly proven success in supporting the ability of fellows to make significant contributions to the scientific literature and to embark on successful academic research careers.

Public Health Relevance

for MAHI/UMKC T32 Training Grant: Medicine is facing an unparalleled demand for scholars capable of quantifying patients'outcomes, defining the determinants of these outcomes, comparing the effectiveness of alternative treatments, translating new knowledge into clinical care, and measuring and improving the quality of care. This proposed T32 program seeks to replace a highly successful American Heart Association- sponsored program to continue training young scholars to independently perform this type of research. In so doing, it will not only meet a national need for such experts, but will also provide a unique educational resource for the Midwestern region of our country.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wells, Barbara L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Missouri Kansas City
Internal Medicine/Medicine
Schools of Medicine
Kansas City
United States
Zip Code
Pokharel, Yashashwi; Steinberg, Lynne; Chan, Winston et al. (2016) Case-based educational intervention to assess change in providers' knowledge and attitudes towards the 2013 American College of Cardiology/American Heart Association Cholesterol Management Guideline. Atherosclerosis 246:115-20
Arnold, Suzanne V; Grodzinsky, Anna; Gosch, Kensey L et al. (2016) Predictors of Physician Under-Recognition of Angina in Outpatients With Stable Coronary Artery Disease. Circ Cardiovasc Qual Outcomes 9:554-9
Pokharel, Yashashwi; Akeroyd, Julia M; Ramsey, David J et al. (2016) Statin Use and Its Facility-Level Variation in Patients With Diabetes: Insight From the Veterans Affairs National Database. Clin Cardiol 39:185-91
Arnold, Suzanne V; Jones, Philip G; Allen, Larry A et al. (2016) Frequency of Poor Outcome (Death or Poor Quality of Life) After Left Ventricular Assist Device for Destination Therapy: Results From the INTERMACS Registry. Circ Heart Fail 9:
Nassif, Michael E; LaRue, Shane J; Raymer, David S et al. (2016) Relationship Between Anticoagulation Intensity and Thrombotic or Bleeding Outcomes Among Outpatients With Continuous-Flow Left Ventricular Assist Devices. Circ Heart Fail 9:
Shafiq, Ali; Jang, Jae-Sik; Kureshi, Faraz et al. (2016) Predicting Likelihood for Coronary Artery Bypass Grafting After Non-ST-Elevation Myocardial Infarction: Finding the Best Prediction Model. Ann Thorac Surg 102:1304-11
Shafiq, Ali; Brawner, Clinton A; Aldred, Heather A et al. (2016) Prognostic value of cardiopulmonary exercise testing in heart failure with preserved ejection fraction. The Henry Ford HospITal CardioPulmonary EXercise Testing (FIT-CPX) project. Am Heart J 174:167-72
Pokharel, Yashashwi; Wei, Jessica; Hira, Ravi S et al. (2016) Guideline-Directed Medication Use in Patients With Heart Failure With Reduced Ejection Fraction in India: American College of Cardiology's PINNACLE India Quality Improvement Program. Clin Cardiol 39:145-9
Grodzinsky, Anna; Goyal, Abhinav; Gosch, Kensey et al. (2016) Prevalence and Prognosis of Hyperkalemia in Patients with Acute Myocardial Infarction. Am J Med 129:858-65
Fendler, Timothy J; Swetz, Keith M; Allen, Larry A (2015) Team-based Palliative and End-of-life Care for Heart Failure. Heart Fail Clin 11:479-98

Showing the most recent 10 out of 23 publications