This T32 renewal application seeks to continue a highly successful postdoctoral training program in cardiovascular outcomes research. It is designed to meet a regional and national need for more scholars in cardiovascular outcomes and quality of care research, especially as healthcare reimbursement transitions from rewarding volume to emphasizing value. It extends and improves the Mid America Heart Institute/University of Missouri-Kansas City (UMKC)?s outcomes research training program, which is unique in the Midwest and serves as the central unifying research program for our region (2 medical schools (UMKC and University of Kansas) and 4 hospital systems). Our program provides a robust foundation with which young investigators can acquire the techniques of cardiovascular outcomes and quality of care research and our objective is to recruit and mentor outstanding potential researchers who are motivated to learn and apply outcomes research principles and techniques in performing comparative effectiveness research and translating existing knowledge to clinical practice. Our 19 multi-disciplinary faculty and 6 advisors are independently funded and specialize in team-based science and collaboration. The 2-year training program has 3 synergistic components: 1) a basic foundation of in clinical research (including a Masters degree in bioinformatics with a clinical research emphasis), 2) specialized skills for outcomes research coupled with academic ?survival skills? (our outcomes-based core curriculum), and 3) hands-on research. Hallmarks of the research experiences include multi-disciplinary group mentorship, individualized to meet the needs of each trainee; access to numerous existing data sources; access to clinical populations for primary data collection and implementation; and highly experienced statistical support. Enhancements planned for the existing program include adding new curricular offerings in entrepreneurship ? a key skill set to sustain and disseminate proven innovations for improving healthcare ? and new training activities for recruiting individuals from diverse backgrounds. Administering the program will be an experienced program director, supported by well-qualified associate and assistant directors. Leaders in methodological cores (economics and decision analysis; large database analysis; bioinformatics; qualitative and implementation research; study design, methodology and statistics; patient and clinician behavior change; community-based participatory research; entrepreneurship; shared medical decision-making and patient-centered research; multi-disciplinary cardiovascular research; disparities research; and risk models and creation of clinical tools) are committed to supporting the training program, as is an advisory committee of national leaders. Collectively, our committed team will provide a formal training, mentorship and evaluation program to continue and enhance our prior success in supporting the ability of trainees to make significant contributions to the scientific literature and to embark on successful academic research careers.

Public Health Relevance

for MAHI/UMKC T32 Training Grant: Recent changes in healthcare reimbursement from a volume- to value-based payments creates an unparalleled demand for scholars capable of quantifying patients? outcomes, defining the determinants of these outcomes, comparing the effectiveness of alternative treatment strategies, translating new knowledge into clinical care, and measuring and improving healthcare quality. This renewal application seeks to continue a highly successful program for training young scholars to independently perform this type of research. Renewal of this T32 training program meets a national need for experts in outcomes and quality of care research, while providing a unique educational resource for the Midwestern region of our country.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL110837-09
Application #
9974559
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Fine, Larry
Project Start
2012-07-01
Project End
2022-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
9
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Missouri Kansas City
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
010989619
City
Kansas City
State
MO
Country
United States
Zip Code
64110
Peri-Okonny, Poghni A; Patel, Krishna K; Jones, Philip G et al. (2018) Low Diastolic Blood Pressure Is Associated With Angina in Patients With Chronic Coronary Artery Disease. J Am Coll Cardiol 72:1227-1232
Pokharel, Yashashwi; Jones, Philip G; Graham, Garth et al. (2018) Racial Heterogeneity in Treatment Effects in Peripheral Artery Disease: Insights From the CLEVER Trial (Claudication: Exercise Versus Endoluminal Revascularization). Circ Cardiovasc Qual Outcomes 11:e004157
Patel, Krishna K; Arnold, Suzanne V; Chan, Paul S et al. (2018) Validation of the Seattle angina questionnaire in women with ischemic heart disease. Am Heart J 201:117-123
Spertus, John A (2018) Understanding How Patients Fare: Insights Into the Health Status Patterns of Patients With Coronary Disease and the Future of Evidence-Based Shared Medical Decision-Making. Circ Cardiovasc Qual Outcomes 11:e004555
Patel, Krishna K; Arnold, Suzanne V; Jones, Philip G et al. (2018) Relation of Age and Health-Related Quality of Life to Invasive Versus Ischemia-Guided Management of Patients with Non-ST Elevation Myocardial Infarction. Am J Cardiol 121:789-795
Khariton, Yevgeniy; Nassif, Michael E; Thomas, Laine et al. (2018) Health Status Disparities by Sex, Race/Ethnicity, and Socioeconomic Status in Outpatients With Heart Failure. JACC Heart Fail 6:465-473
Khariton, Yevgeniy; Hernandez, Adrian F; Fonarow, Gregg C et al. (2018) Health Status Variation Across Practices in Outpatients With Heart Failure: Insights From the CHAMP-HF (Change the Management of Patients With Heart Failure) Registry. Circ Cardiovasc Qual Outcomes 11:e004668
Patel, Krishna K; Spertus, John A; Khariton, Yevgeniy et al. (2018) Association Between Prompt Defibrillation and Epinephrine Treatment With Long-Term Survival After In-Hospital Cardiac Arrest. Circulation 137:2041-2051
Jayaram, Natalie M; Khariton, Yevgeniy; Krumholz, Harlan M et al. (2017) Impact of Telemonitoring on Health Status. Circ Cardiovasc Qual Outcomes 10:
Nassif, Michael E; Tang, Yuanyuan; Cleland, John G et al. (2017) Precision Medicine for Cardiac Resynchronization: Predicting Quality of Life Benefits for Individual Patients-An Analysis From 5 Clinical Trials. Circ Heart Fail 10:

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