This CTSA renewal application is built on the research infrastructure, training programs, and partnerships we established in the first grant period, through creation ofthe Institute for Clinical and Translational Sciences (ICTS), which brought about significant cultural and organizational changes at Washington University in St. Louis and unprecedented collaboration between its partner institutions, including BJC HealthCare, Barnes-Jewish Hospital, St. Louis Children's Hospital, Saint Louis University, University of Missouri - St. Louis, Southern Illinois University Edwardsville, Goldfarb School of Nursing at Barnes-Jewish College, and the St. Louis College of Pharmacy. The overall goal of this application is to promote the translation of scientific discoveries into improvements in human health.
Our specific aims will transform our research support infrastructure to foster multidisciplinary clinical and translational research, expand and enhance clinical and translational research education programs, and promote communication and collaborative research with regional and national partners. New initiatives include 3 new cross-cutting scientific themes where the resources of our ICTS are most likely to result in high-impact clinical research and its subsequent translation into clinical practice: translating the findings of genetic/genomic research into clinical research and practice, accelerating the development and evaluation of new therapeutics, and conducting comparative effectiveness and dissemination and implementation research to improve the transfer of research into practice. To ensure the continued success ofthe ICTS, WU has made significant commitments of space and financial support. Barnes-Jewish Hospital and St. Louis Children's Hospital, our academic hospital partners, and BJC HealthCare, our affiliated health system, have also made substantial commitments to suppport the clinical and translational research activities ofthe ICTS. This institutional support, combined with the programs and collaborations we have started in the past four years, ensure that the ICTS will continue to make outstanding contributions in clinical and translational science.
The overall goal of this grant is to promote the translation of scientific discoveries into improvements in human health. Our proposal will improve clinical research infrastructure, services, and training programs in order to speed the translation of new discoveries from the lab into humans, and to help implement the best medical evidence into clinical practice.
|Kadkhodayan, Ana; Lin, C Huie; Coggan, Andrew R et al. (2017) Sex affects myocardial blood flow and fatty acid substrate metabolism in humans with nonischemic heart failure. J Nucl Cardiol 24:1226-1235|
|Iseyemi, Abigail; Zhao, Qiuhong; McNicholas, Colleen et al. (2017) Socioeconomic Status As a Risk Factor for Unintended Pregnancy in the Contraceptive CHOICE Project. Obstet Gynecol 130:609-615|
|Xiao, Daphne Y; Luo, Suhong; O'Brian, Katiuscia et al. (2017) Weight change trends and overall survival in United States veterans with follicular lymphoma treated with chemotherapy. Leuk Lymphoma 58:851-858|
|Slade, Michael; Goldsmith, Scott; Romee, Rizwan et al. (2017) Epidemiology of infections following haploidentical peripheral blood hematopoietic cell transplantation. Transpl Infect Dis 19:|
|Beleckas, Casey M; Padovano, Alex; Guattery, Jason et al. (2017) Performance of Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity (UE) Versus Physical Function (PF) Computer Adaptive Tests (CATs) in Upper Extremity Clinics. J Hand Surg Am 42:867-874|
|Denny, George; Anadkat, Milan J (2017) The effect of smoking and age on the response to first-line therapy of hidradenitis suppurativa: An institutional retrospective cohort study. J Am Acad Dermatol 76:54-59|
|Bali, Taha; Self, Wade; Liu, Jingxia et al. (2017) Defining SOD1 ALS natural history to guide therapeutic clinical trial design. J Neurol Neurosurg Psychiatry 88:99-105|
|Stephens, Robert J; Dettmer, Matthew R; Roberts, Brian W et al. (2017) Practice Patterns and Outcomes Associated With Early Sedation Depth in Mechanically Ventilated Patients: A Systematic Review and Meta-Analysis. Crit Care Med :|
|Roland, Lauren T; Skillington, S Andrew; Ogden, M Allison (2017) Sialendoscopy-assisted transfacial removal of parotid sialoliths: A systematic review and meta-analysis. Laryngoscope 127:2510-2516|
|Ban, Norimitsu; Siegfried, Carla J; Lin, Jonathan B et al. (2017) GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients. JCI Insight 2:|
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