Between 2002-2008, the Chronic Renal Insufficiency Cohort (CRIC) Study enrolled 3,939 adults with chronic kidney disease (CKD) at 7 Clinical Centers to address overarching goals of identifying risk factors for CKD progression and clarifying the relationship between kidney dysfunction and the risks of subclinical and clinical cardiovascular events and mortality. Phase 2 of CRIC extended follow-up through April 30, 2013. This application is submitted in response to RFA-DK-12-508, """"""""Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01),"""""""" on behalf of the Hopkins and University of Maryland (U.MD) Clinical Center. In Phase 3, the Hopkins/U.MD center has the following specific aims: 1. To re-enroll current participants [total of ~362 (203 a Hopkins, 159 at U.MD)] 2. To enroll an additional 215 participants into Phase 3 of CRIC 3. To collect exposure and outcome data per the CRIC Phase 3 protocol 4. To maintain high levels of retention in the study 5. To investigate self-reported clinical events and obtain supporting medical records and documentation. 6. To enter data and collect/process/ship biological specimens. 7. To implement local quality assurance and quality control procedures as a means to obtain standardized, high quality measurements 8. To monitor data collection, data entry, and follow-up rates 9. To participate in governance and oversight of CRIC through study wide subcommittees and activities 10. To publish and present findings from the CRIC Study 11. To promote and support the conduct of ancillary studies in CRIC, including collaboration with the broader nephrology research community. The investigative teams at Hopkins and U.MD have vast experience in the design and implementation of rigorously conducted, influential research. During Phases 1+2, the Hopkins and U.MD Center was a high performing center that exceeded its recruitment goal;achieved high follow-up rates;and collected high quality data. Likewise, center investigators have consistently had prominent leadership roles (e.g. Co-Chairs of Recruitment and Retention, Ancillary Studies, and Publications Executive Subcommittees). In Phase 3, we remain extremely well-positioned to successfully implement the study. On a final note, we remain deeply committed to the success of CRIC and look forward to providing strong scientific leadership in this tremendously important research effort.
Chronic Kidney Disease is an extremely common medical problem. The consequences of chronic kidney disease include kidney failure requiring dialysis or a kidney transplant;cardiovascular disease and stroke;physical and cognitive disabilities;and premature death. The Chronic Renal Insufficiency Cohort (CRIC) Study is a long-term, observational study designed to evaluate factors that might be responsible for these adverse outcomes in adults with chronic kidney disease.
|Bansal, Nisha; McCulloch, Charles E; Lin, Feng et al. (2016) Different components of blood pressure are associated with increased risk of atherosclerotic cardiovascular disease versus heart failure in advanced chronic kidney disease. Kidney Int 90:1348-1356|
|Porter, Anna C; Lash, James P; Xie, Dawei et al. (2016) Predictors and Outcomes of Health-Related Quality of Life in Adults with CKD. Clin J Am Soc Nephrol 11:1154-62|
|Liu, Xun; Foster, Meredith C; Tighiouart, Hocine et al. (2016) Non-GFR Determinants of Low-Molecular-Weight Serum ProteinÂ Filtration Markers in CKD. Am J Kidney Dis 68:892-900|
|Dobre, Mirela; Roy, Jason; Tao, Kaixiang et al. (2016) Serum Bicarbonate and Structural and Functional Cardiac Abnormalities in Chronic Kidney Disease - A Report from the Chronic Renal Insufficiency Cohort Study. Am J Nephrol 43:411-20|
|Gupta, Jayanta; Mitra, Nandita; Townsend, Raymond R et al. (2016) Variants in genes belonging to the fibroblast growth factor family are associated with lower extremity amputation in non-Hispanic whites: Findings from the chronic renal insufficiency cohort study. Wound Repair Regen 24:705-11|
|Inker, Lesley A; Tighiouart, Hocine; Coresh, Josef et al. (2016) GFR Estimation Using Î²-Trace Protein and Î²2-Microglobulin inÂ CKD. Am J Kidney Dis 67:40-8|
|Ricardo, Ana C; Roy, Jason A; Tao, Kaixiang et al. (2016) Influence of Nephrologist Care on Management and Outcomes in Adults with Chronic Kidney Disease. J Gen Intern Med 31:22-9|
|Kurella Tamura, Manjula; Vittinghoff, Eric; Yang, Jingrong et al. (2016) Anemia and risk for cognitive decline in chronic kidney disease. BMC Nephrol 17:13|
|Deo, Rajat; Shou, Haochang; Soliman, Elsayed Z et al. (2016) Electrocardiographic Measures and Prediction of Cardiovascular and Noncardiovascular Death in CKD. J Am Soc Nephrol 27:559-69|
|Drawz, Paul E; Alper, Arnold B; Anderson, Amanda H et al. (2016) Masked Hypertension and Elevated Nighttime Blood Pressure in CKD: Prevalence and Association with Target Organ Damage. Clin J Am Soc Nephrol 11:642-52|
Showing the most recent 10 out of 62 publications