The Environmental Determinants of Diabetes in the Young (TEDDY), a multicenter prospective cohort study, was initiated in 2003 to identify environmental factors that trigger or protect against the development of islet autoimmunity and type 1 diabetes (T1D). A successful study outcome should allow better understanding of the etiology and pathogenesis of T1D and the development of new strategies to prevent, delay, or reverse the disease. Newborns are screened by HLA-DR,DQ genotyping to identify those at increased risk for T1D. Eligible children are followed four times per year until 4 years of age and twice a year thereafter until 15 years of age.
The specific aims of the GA/FL Clinical Center renewal application are to: 1) Complete our contribution to the HLA-DR,DQ screening of 361,000 newborns and enrollment of 7,800 high-risk infants into intensive prospective follow-up to achieve the overall TEDDY goals, 2) Refine strategies to retain subjects enrolled in the follow-up and collect all planned biological specimens and epidemiological data according to the standard protocol including close monitoring of performance and sample/data quality, 3) Ascertain prospectively development of islet autoantibodies and clinical T1D in the study subjects, 4) Perform planned laboratory tests at appropriate times using a nested case-control study design to answer specific scientific questions and hypotheses pertinent to the TEDDY study goals, 5) Analyze and publish laboratory and epidemiological data in collaboration with other TEDDY clinical centers and the Data Coordinating Center, 6) Guide the ongoing TEDDY project by participation of the Clinical Center investigators and staff in work of the study Steering Committee and sub-committees. These proposed activities are essential to achieve the following long-term scientific goals: 1) To identify environmental factors (infectious, dietary, psychosocial factors, toxins, allergens, etc) that trigger or protect against the development of islet autoantibodies or T1 D. 2) To assess potential gene-environment interactions to improve identification of environmental factors affecting development of islet autoimmunity or T1D, and to gain insight on mechanisms. 3) Collect and bank specimens for studies of T1D pathogenesis and development of biomarkers for T1D prediction. The prospectively collected specimens on TEDDY subjects provide a unique opportunity for scientists within and outside the TEDDY consortium to test novel hypotheses by performing otherwise impossible critical studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK063865-09
Application #
8094463
Study Section
Special Emphasis Panel (ZDK1-GRB-G (J1))
Program Officer
Spain, Lisa M
Project Start
2003-03-01
Project End
2013-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
9
Fiscal Year
2011
Total Cost
$318,653
Indirect Cost
Name
Georgia Regents University
Department
Pathology
Type
Schools of Medicine
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912
Köhler, Meike; Beyerlein, Andreas; Vehik, Kendra et al. (2017) Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study. Acta Diabetol 54:1009-1017
Lönnrot, Maria; Lynch, Kristian F; Elding Larsson, Helena et al. (2017) Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study. Diabetologia 60:1931-1940
Johnson, Suzanne Bennett; Lynch, Kristian F; Roth, Roswith et al. (2017) My Child Is Islet Autoantibody Positive: Impact on Parental Anxiety. Diabetes Care 40:1167-1172
Kemppainen, Kaisa M; Vehik, Kendra; Lynch, Kristian F et al. (2017) Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity. JAMA Pediatr 171:1217-1225
Koletzko, Sibylle; Lee, Hye-Seung; Beyerlein, Andreas et al. (2017) Caesarean Section on The Risk of Celiac Disease in the Offspring: The Teddy Study. J Pediatr Gastroenterol Nutr :
Yang, Jimin; Tamura, Roy N; Aronsson, Carin A et al. (2017) Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Br J Nutr 117:466-472
Joslowski, Gesa; Yang, Jimin; Aronsson, Carin Andrén et al. (2017) Development of a harmonized food grouping system for between-country comparisons in the TEDDY Study. J Food Compost Anal 63:79-88
Kemppainen, Kaisa M; Lynch, Kristian F; Liu, Edwin et al. (2017) Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life. Clin Gastroenterol Hepatol 15:694-702.e5
Hummel, Sandra; Beyerlein, Andreas; Tamura, Roy et al. (2017) First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Diabetes Care 40:398-404
Smith, Laura B; Lynch, Kristian F; Kurppa, Kalle et al. (2017) Psychological Manifestations of Celiac Disease Autoimmunity in Young Children. Pediatrics 139:

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