This proposal responds to RFA of -DK-07-003, which requests applications for Discovery Centers to collaborate with other Discovery Centers in a Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. In this application, the University of Washington (UW) seeks support for a Discovery Center to participate in efforts to unravel the enigma of what has been termed urologic chronic pelvic pain syndromes (UCPPS) by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This proposal was developed following the guidelines stipulated by the NIDDK for Program Project Grants and Cooperative Agreements.
The aims of these Discovery Centers, in conjunction with the Tissue Analysis and Technology Core and the Data Coordination Core, are to conduct multi-disciplinary, multi-site, basic, translational, and clinical research in the field of UCPPS. The goals of the MAPP Research Network are to 1) identify UCPPS disease phenotypes;2) determine how UCPPS fit into the larger spectrum of related chronic pain syndromes (RCPS);3) conduct targeted epidemiological studies of UCPPS using relevant patient populations;and 4) use basic cellular, molecular, and biochemical techniques to examine the pathophysiology of UCPPS. More broadly, each site will need to collaborate closely with NIDDK staff and other Network Centers to complete multidisciplinary, multi-site, and highly interactive studies, and to obtain specimens for basic science studies. In addition, Discovery Centers will need the flexibility to accept and implement new and perhaps unconventional UCPPS definitions, and to both import and export study designs and methods pertinent to UCPPS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK082325-05
Application #
8334701
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M1))
Program Officer
Mullins, Christopher V
Project Start
2008-09-15
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$876,789
Indirect Cost
$345,161
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Afari, Niloofar; Ahumada, Sandra M; Wright, Lisa Johnson et al. (2014) Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis. Psychosom Med 76:2-11
Clemens, J Quentin; Mullins, Chris; Kusek, John W et al. (2014) The MAPP research network: a novel study of urologic chronic pelvic pain syndromes. BMC Urol 14:57
Landis, J Richard; Williams, David A; Lucia, M Scott et al. (2014) The MAPP research network: design, patient characterization and operations. BMC Urol 14:58
Godfrey, Kathryn M; Strachan, Eric; Dansie, Elizabeth et al. (2014) Salivary cortisol and cold pain sensitivity in female twins. Ann Behav Med 47:180-8
Kilpatrick, Lisa A; Kutch, Jason J; Tillisch, Kirsten et al. (2014) Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. J Urol 192:947-55
Bullones Rodriguez, Maria Angeles; Afari, Niloofar; Buchwald, Dedra S et al. (2013) Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol 189:S66-74
Jimenez, Nathalia; Ebel, Beth E; Wang, Jin et al. (2013) Disparities in disability after traumatic brain injury among Hispanic children and adolescents. Pediatrics 131:e1850-6
Jimenez, Nathalia; Dansie, Elizabeth; Buchwald, Dedra et al. (2013) Pain among older Hispanics in the United States: is acculturation associated with pain? Pain Med 14:1134-9
Yang, Claire C (2013) Neuromodulation in male chronic pelvic pain syndrome: rationale and practice. World J Urol 31:767-72
Jimenez, Nathalia; Anderson, Gail D; Shen, Danny D et al. (2012) Is ethnicity associated with morphine's side effects in children? Morphine pharmacokinetics, analgesic response, and side effects in children having tonsillectomy. Paediatr Anaesth 22:669-75

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