We will apply transdisciplinary, data-driven and multi-scale modeling approaches to inform timely policy decisions. We will specifically evaluate the effectiveness and cost-effectiveness of vaccination strategies to control rabies, polio and pertussis. Our models will capture epidemiological, clinical, behavioral and socio- economic factors pertinent to the implementation, effectiveness and health economics of policy decisions. Our results will enhance our understanding of health decision-making and inform intervention strategies to improve vaccination rates nationally and internationally.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
4U01GM105627-04
Application #
9041630
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Marcus, Stephen
Project Start
2013-07-10
Project End
2018-03-31
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Yale University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
Medley, Graham F; Blok, David J; Crump, Ronald E et al. (2018) Policy Lessons From Quantitative Modeling of Leprosy. Clin Infect Dis 66:S281-S285
Rock, Kat S; Ndeffo-Mbah, Martial L; CastaƱo, Soledad et al. (2018) Assessing Strategies Against Gambiense Sleeping Sickness Through Mathematical Modeling. Clin Infect Dis 66:S286-S292
Sah, Pratha; Medlock, Jan; Fitzpatrick, Meagan C et al. (2018) Optimizing the impact of low-efficacy influenza vaccines. Proc Natl Acad Sci U S A 115:5151-5156
Durham, David P; Fitzpatrick, Meagan C; Ndeffo-Mbah, Martial L et al. (2018) Evaluating Vaccination Strategies for Zika Virus in the Americas. Ann Intern Med 168:621-630
Marshall, Brandon D L; Goedel, William C; King, Maximilian R F et al. (2018) Potential effectiveness of long-acting injectable pre-exposure prophylaxis for HIV prevention in men who have sex with men: a modelling study. Lancet HIV 5:e498-e505
Grantz, Kyra H; Chabaari, Winnie; Samuel, Ramolotja Kagiso et al. (2018) Spatial distribution of leprosy in India: an ecological study. Infect Dis Poverty 7:20
Fitzpatrick, Meagan C; Gray, Glenda E; Galvani, Alison P (2018) The Challenge of Vanquishing HIV for the Next Generation-Facing the Future. JAMA Pediatr 172:609-610
Ndeffo-Mbah, Martial L; Vigliotti, Vivian S; Skrip, Laura A et al. (2018) Dynamic Models of Infectious Disease Transmission in Prisons and the General Population. Epidemiol Rev 40:40-57
Lee, Bruce Y; Bartsch, Sarah M; Skrip, Laura et al. (2018) Are the London Declaration's 2020 goals sufficient to control Chagas disease?: Modeling scenarios for the Yucatan Peninsula. PLoS Negl Trop Dis 12:e0006337
Galvani, Alison P; Durham, David P; Vermund, Sten H et al. (2017) California Universal Health Care Bill: an economic stimulus and life-saving proposal. Lancet 390:2012-2014

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