Cancer and many other human diseases are both genetic and epigenetic, and a large body of work has implicated chromatin-based processes as being largely responsible for the epigenetic component. Our development and application of a new tool for chromatin profiling in modENCODE model organisms was a necessary first step in applying these methods to human material as represented by the ENCODE project. Furthermore, what we expect to learn from human genome-wide mapping using the novel tools that we have developed is expected to provide a physical basis for the delineation of chromatin properties and epigenetic marks.
| Steiner, Florian A; Henikoff, Steven (2015) Cell type-specific affinity purification of nuclei for chromatin profiling in whole animals. Methods Mol Biol 1228:3-14 |
| Orsi, Guillermo A; Kasinathan, Sivakanthan; Hughes, Kelly T et al. (2014) High-resolution mapping defines the cooperative architecture of Polycomb response elements. Genome Res 24:809-20 |
| Zentner, Gabriel E; Henikoff, Steven (2014) High-resolution digital profiling of the epigenome. Nat Rev Genet 15:814-27 |
| Steiner, Florian A; Henikoff, Steven (2014) Holocentromeres are dispersed point centromeres localized at transcription factor hotspots. Elife 3:e02025 |
| Teves, Sheila S; Henikoff, Steven (2014) Transcription-generated torsional stress destabilizes nucleosomes. Nat Struct Mol Biol 21:88-94 |
| Zentner, Gabriel E; Henikoff, Steven (2013) Mot1 redistributes TBP from TATA-containing to TATA-less promoters. Mol Cell Biol 33:4996-5004 |
| Zentner, Gabriel E; Tsukiyama, Toshio; Henikoff, Steven (2013) ISWI and CHD chromatin remodelers bind promoters but act in gene bodies. PLoS Genet 9:e1003317 |
| Zentner, Gabriel E; Henikoff, Steven (2013) Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol 20:259-66 |
| Zentner, Gabriel E; Henikoff, Steven (2012) Surveying the epigenomic landscape, one base at a time. Genome Biol 13:250 |
| Ooi, Siew Loon; Henikoff, Jorja G; Henikoff, Steven (2010) A native chromatin purification system for epigenomic profiling in Caenorhabditis elegans. Nucleic Acids Res 38:e26 |
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