Age-related macular degeneration (AMD) is the leading cause of blindness in the United States and most western countries. The Comparison of AMD Treatment Trials (CATT) is a set of large-scale, randomized clinical trials designed to evaluate the relative efficacy and safety of alternative treatments for the neovascular form of the disease that accounts for approximately 90% of blindness due to AMD. The goal of the Coordinating Center is to contribute to the success of the CATT by providing study leadership, data management, data analysis, and communication, by facilitating the execution of the study protocol, and by coordinating the activities of the study group. The Coordinating Center provides expertise on design of multicenter clinical trials, implementation and maintenance of high quality data management systems, statistical analysis, and quality assurance in data management and clinical center performance. ? ? The specific aims of the Coordinating Center to fulfill this role are: Work with the other members of the study group to further refine the study design; Create and maintain the study database through design of data collection forms, data capture, data editing, and data management; Provide timely, regular reports concerning study progress and performance to the clinical sites, OCT Reading Center, Fundus Photograph Reading Center, Executive Committee and its subcommittees, and the Data and Safety Monitoring Committee; Design and implement a full program of quality assurance activities, in conjunction with the Executive Committee; Provide interim and final statistical analysis of the accumulated data on primary and secondary outcomes, as well as ancillary studies; Contribute to and distribute support materials for all CATT meetings; Maintain an up-to-date assessment of the status of treatments for AMD that are under development; Participate and lead in the preparation of scientific presentations and reports. Administer subcontracts with CATT clinical centers and work with the Center for Medicare and Medicaid Services to provide clinical centers with reimbursement for patient care; The CATT will identify the best treatments for """"""""wet"""""""" age-related macular degeneration, the leading cause of blindness in Americans. The Coordinating Center works to make sure the clinical trials are successful. ? ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
1U10EY017823-01
Application #
7171668
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Redford, Maryann
Project Start
2006-09-30
Project End
2010-08-31
Budget Start
2006-09-30
Budget End
2007-08-31
Support Year
1
Fiscal Year
2006
Total Cost
$3,899,032
Indirect Cost
Name
University of Pennsylvania
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Song, Delu; Ying, Gui-Shuang; Dunaief, Joshua L et al. (2018) ASSOCIATION BETWEEN ORAL IRON SUPPLEMENTATION AND RETINAL OR SUBRETINAL HEMORRHAGE IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS. Retina :
Daniel, Ebenezer; Ying, Gui-Shuang; Kim, Benjamin J et al. (2018) Follow up at 5 Years of Non-Fibrotic Scars in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). Ophthalmology :
Ying, Gui-Shuang; Maguire, Maureen G; Pan, Wei et al. (2018) Baseline Predictors for Five-Year Visual Acuity Outcomes in the Comparison of AMD Treatment Trials. Ophthalmol Retina 2:525-530
Rahimy, Ehsan; Ying, Gui-Shuang; Pan, Wei et al. (2018) EFFECT OF INTRAOCULAR PRESSURE-LOWERING MEDICATIONS ON NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATMENT OUTCOMES IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENT TRIALS. Retina :
Daniel, Ebenezer; Pan, Wei; Ying, Gui-Shuang et al. (2018) Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology 125:1037-1046
Grunwald, Juan E; Pistilli, Maxwell; Daniel, Ebenezer et al. (2017) Incidence and Growth of Geographic Atrophy during 5 Years of Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology 124:97-104
Daniel, Ebenezer; Grunwald, Juan E; Kim, Benjamin J et al. (2017) Visual and Morphologic Outcomes in Eyes with Hard Exudate in the Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmol Retina 1:25-33
Zhou, Qiang; Daniel, Ebenezer; Grunwald, Juan E et al. (2017) Association between pseudodrusen and delayed patchy choroidal filling in the comparison of age-related macular degeneration treatments trials. Acta Ophthalmol 95:e518-e520
Bevacizumab-Ranibizumab International Trials Group (2017) Serious Adverse Events with Bevacizumab or Ranibizumab for Age-related Macular Degeneration: Meta-analysis of Individual Patient Data. Ophthalmol Retina 1:375-381
Zhou, Qiang; Daniel, Ebenezer; Maguire, Maureen G et al. (2016) Pseudodrusen and Incidence of Late Age-Related Macular Degeneration in Fellow Eyes in the Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology 123:1530-40

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