A major goal of the neuroscience community is to develop treatment strategies that will slow or forestall the progression of chronic neurodegenerative diseases. Parkinson's disease (PD) is one of the most common adult neurodegenerative disorders, affecting over 1 million people in North America and the European Union. As a first step in identifying such therapies, the NINDS Exploratory Trials in Parkinson's disease (NET-PD) network successfully completed futility studies, which identified creatine as a potential agent to slow clinical decline in PD. The NET-PD network is now conducting a large, long-term. Phase 3 trial (known as LS1) comparing creatine to placebo. The Movement Disorders Program at the Medical University of South Carolina (MUSC) was awarded the U10 NS053372 award as a Parkinson's Disease Neuroprotection Clinical Trial Center in 2006 and is one of the current sites for the LS1 study with 36 study local study participants. With this application, MUSC seeks out funding to continue the LS1 study for 3 additional years, and to continue cooperating with the other NET-PD centers (including the Coordination and Statistical Centers) towards the goal of successfully completing the current trials.

Public Health Relevance

The accumulated disability that Parkinson's Disease causes is a major source of diminished quality of life and increased health care costs. Despite the advances in our understanding of the pathophysiology in PD, there are no current therapies that slow the inexorable clinical decline. LS1 will help to determine if creatine can slow clinical decline and provide better information on the course of early PD than is currently available.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10NS053372-06
Application #
8460303
Study Section
Special Emphasis Panel (ZNS1-SRB-B (34))
Program Officer
Moy, Claudia S
Project Start
2006-05-17
Project End
2015-11-30
Budget Start
2013-01-01
Budget End
2013-11-30
Support Year
6
Fiscal Year
2013
Total Cost
$66,095
Indirect Cost
$34,186
Name
Medical University of South Carolina
Department
Neurosciences
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Seidel, Sydney E; Tilley, Barbara C; Huang, Peng et al. (2012) Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale. Parkinsonism Relat Disord 18:230-3