Pneumonia remains the leading infectious cause of morbidity and mortality in the United States. In spite of its substantial public health burden, recent measurements of pneumonia incidence in the United States are surprisingly scarce and differences in research methodologies make the comparison of available estimates problematic. Moreover, our current knowledge of the distribution of etiologic organisms for community-acquired pneumonia (CAP) is limited and largely based on case series or studies performed decades ago or abroad. The availability of novel molecular techniques provides opportunities to reassess this knowledge systematically. Without current large-scale population-based studies to inform clinicians about the most likely etiologies of pneumonia and the identification of resistant organisms, clinicians would continue to assess and treat patients with pneumonia as they have for the past several decades. Since January 2010 we have conducted active population-based surveillance for pneumonia in subjects of all ages through the CDC-funded study, """"""""The incidence and etiology of influenza-associated pneumonia in hospitalized persons."""""""" The procedures for enrolling and testing eligible pneumonia patients have been well established;data collection forms have been developed and tested;CDC-endorsed laboratory procedures have been established; extensive data are now being collected and systematically entered into the master project databases;and radiographs from each pneumonia case are being evaluated by study radiologists. With these well established study methodologies and experience, we are well positioned to continue the CDC-funded pneumonia project for two additional years. We propose to use our existing infrastructure, skilled personnel, network capabilities, and previous experience to perform a multicenter, population-based, prospective cohort study to determine the incidence and etiologies of pneumonia leading to hospitalization for both children and adults. Our project encompasses the following specific aims: 1)To determine the incidence of hospitalization for community- acquired pneumonia in children and adults living in Middle Tennessee;2) To determine the relative contributions of the different respiratory pathogens to the etiology of community-acquired pneumonia in children and adults hospitalized in Middle Tennessee;and, 3)To establish the burden of influenza associated with community-acquired pneumonia in children and adults hospitalized in Middle Tennessee.

Public Health Relevance

Contemporary, prospective, population-based studies on the burden of community-acquired pneumonia and its etiology are scarce;this information is critical to revising current treatment guidelines and for the efficient allocation of healthcare resources. We are currently conducting population-based surveillance of pneumonia hospitalizations for children and adults in middle Tennessee. We propose to continue the conduct of these studies to conclusively determine the burden and etiology of community-acquired pneumonia in the US for two more years.

National Institute of Health (NIH)
National Center for Immunication and Respiratory Diseases (NCIRD)
Research Demonstration--Cooperative Agreements (U18)
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Special Emphasis Panel (ZIP1-GCA (21))
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Yang, Amy
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Vanderbilt University Medical Center
Schools of Medicine
United States
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Millman, Alexander J; Finelli, Lyn; Bramley, Anna M et al. (2016) Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders. J Pediatr 173:188-195.e4
Grijalva, Carlos G; Zhu, Yuwei; Williams, Derek J et al. (2015) Association Between Hospitalization With Community-Acquired Laboratory-Confirmed Influenza Pneumonia and Prior Receipt of Influenza Vaccination. JAMA 314:1488-97
Jain, Seema; Williams, Derek J; Arnold, Sandra R et al. (2015) Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med 372:835-45
Jain, Seema; Self, Wesley H; Wunderink, Richard G et al. (2015) Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. N Engl J Med 373:415-27