The goal of this Pilot Project Program is to continue to provide funding, access to core facilities, and intellectual support for Pilot Research / Development Projects. In the review procedure, there will be an emphasis on junior investigators and others new to the field of radiation countermeasure development;pilot project collaborations with other members ofthe CMCR network will also be given priority. The broad objective of the program is to provide eariy stage support to foster innovative, exploratory, and developmental R&D projects, which have the potential to lead to practical products in the field of high throughput radiation biodosimetry. To date, the Pilot Program has awarded to 21 pilot projects over the course of this grant. Investigators from 4 departments at Columbia University and 9 other institutions in the USA, Germany, and Australia were awarded pilot projects. Research initiated in these pilot grants has resulted in 6 federal grants/contracts being awarded, 7 patent applications, and 34 peer-reviewed publications (23 published, 5 in press and 6 submitted). Investigators have presented their results at National and International meetings Pilot projects have been and will continue to be solicited and evaluated using a novel two-stage approach, by our Internal Advisory Committee and then by our External Scientific Advisory Group. Progress will continue to be monitored and evaluated on a regular basis.

Public Health Relevance

A large scale radiological event could result in mass casualties from multiple types of radiation exposures, and there is thus a need for rapid, high-throughput biodosimetry to identify those who most require treatment. The Pilot Project Core will support innovative projects with potential to contribute towards high throughput biodosimetry, and also for potentially identifying individuals with particular sensitivities to radiation.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-KS-I)
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Columbia University (N.Y.)
New York
United States
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Zhou, Shuanhu; Glowacki, Julie (2017) Chronic kidney disease and vitamin D metabolism in human bone marrow-derived MSCs. Ann N Y Acad Sci 1402:43-55
Repin, Mikhail; Pampou, Sergey; Karan, Charles et al. (2017) RABiT-II: Implementation of a High-Throughput Micronucleus Biodosimetry Assay on Commercial Biotech Robotic Systems. Radiat Res 187:492-498
Lee, Jaewoo; Jackman, Jennifer G; Kwun, Jean et al. (2017) Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis. Biomaterials 120:94-102
Shuryak, Igor; Loucas, Bradford D; Cornforth, Michael N (2017) Straightening Beta: Overdispersion of Lethal Chromosome Aberrations following Radiotherapeutic Doses Leads to Terminal Linearity in the Alpha-Beta Model. Front Oncol 7:318
Garty, Guy; Xu, Yanping; Elliston, Carl et al. (2017) Mice and the A-Bomb: Irradiation Systems for Realistic Exposure Scenarios. Radiat Res 187:465-475
Hei, Tom K; Amundson, Sally A (2017) Preface from the Guest Editors. Radiat Res 187:405
Broustas, Constantinos G; Xu, Yanping; Harken, Andrew D et al. (2017) Impact of Neutron Exposure on Global Gene Expression in a Human Peripheral Blood Model. Radiat Res 187:433-440
Marino, Stephen A (2017) 50 Years of the Radiological Research Accelerator Facility (RARAF). Radiat Res 187:413-423
Vendetti, Frank P; Leibowitz, Brian J; Barnes, Jennifer et al. (2017) Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation. Sci Rep 7:41892
Lacombe, Jerome; Brooks, Carla; Hu, Chengcheng et al. (2017) Analysis of Saliva Gene Expression during Head and Neck Cancer Radiotherapy: A Pilot Study. Radiat Res 188:75-81

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