Malaria remains one of the most important global health challenges, with an estimated 3 billion people at risk of infection, leading to approximately 250 million cases and 1 million deaths each year. The greatest burden of malaria, by far, remains in the heartland of Africa, characterized by large contiguous areas of high transmission, low coverage of proven control interventions, and limited Infrastructure to monitor trends in malaria burden and measure the impact of interventions. The overall purpose of this program will be to establish an International Center of Excellence In Malaria Research in Uganda and perform comprehensive surveillance studies aimed to improve understanding of the disease and measure the impact of population-level control interventions. Uganda provides an ideal environment for this program, where malaria covers a wide range of epidemiological settings. Studies will be conducted in six sentinel sites, ranging from areas of relatively low transmission intensity to areas with some of the highest transmission intensities recorded in the world. Our comprehensive approach to surveillance will bring together expertise from multiple disciplines to collect data across multiple levels, reflecting the complex nature of interactions between the mosquito vector, malaria parasite and human host. The program will consist of 4 research projects linked together in an integrated manner to maximize scientific discovery. Research project 1 will compare different malaria surveillance methodologies and measure the impact and cost-effectiveness of control interventions. Research project 2 will use a modeling approach to evaluate the optimal suites of malaria control interventions in different transmission settings. Research project 3 will investigate the role of immunological assays for estimating transmission intensity and predicting disease risk. Research project 4 will identify markers of antimalarial drug and insecticide resistance and investigate the role of these markers as malaria surveillance tools. In addition to the research activities described, this program will place a strong emphasis on local training and capacity building, the transfer of technology, and building strong relationships between researchers and policy makers.

Public Health Relevance

Recent increases in funding and resources have provided Africa with the opportunity to greatly reduce the burden of malaria. However, gaps in knowledge remain as to the optimal approaches to malaria control in different epidemiological setting. This program will address these gaps by performing comprehensive surveillance studies to improve understanding of malaria and measure the impact of control interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089674-04
Application #
8501273
Study Section
Special Emphasis Panel (ZAI1-AWA-M (M2))
Program Officer
Rao, Malla R
Project Start
2010-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$2,058,047
Indirect Cost
$243,375
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Katrak, Shereen; Nayebare, Patience; Rek, John et al. (2018) Clinical consequences of submicroscopic malaria parasitaemia in Uganda. Malar J 17:67
Meerstein-Kessel, Lisette; Andolina, Chiara; Carrio, Elvira et al. (2018) A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes. Malar J 17:441
Glennon, Elizabeth K K; Megawati, Dewi; Torrevillas, Brandi K et al. (2018) Elevated plasma abscisic acid is associated with asymptomatic falciparum malaria and with IgG-/caspase-1-dependent immunity in Plasmodium yoelii-infected mice. Sci Rep 8:8896
James, W H M; Tejedor-Garavito, N; Hanspal, S E et al. (2018) Gridded birth and pregnancy datasets for Africa, Latin America and the Caribbean. Sci Data 5:180090
Utazi, C Edson; Sahu, Sujit K; Atkinson, Peter M et al. (2018) Geographic coverage of demographic surveillance systems for characterising the drivers of childhood mortality in sub-Saharan Africa. BMJ Glob Health 3:e000611
Isaacs, Alison T; Mawejje, Henry D; Tomlinson, Sean et al. (2018) Genome-wide transcriptional analyses in Anopheles mosquitoes reveal an unexpected association between salivary gland gene expression and insecticide resistance. BMC Genomics 19:225
Wesolowski, Amy; Winter, Amy; Tatem, Andrew J et al. (2018) Measles outbreak risk in Pakistan: exploring the potential of combining vaccination coverage and incidence data with novel data-streams to strengthen control. Epidemiol Infect 146:1575-1583
Weetman, David; Wilding, Craig S; Neafsey, Daniel E et al. (2018) Candidate-gene based GWAS identifies reproducible DNA markers for metabolic pyrethroid resistance from standing genetic variation in East African Anopheles gambiae. Sci Rep 8:2920
Rodriguez-Barraquer, Isabel; Arinaitwe, Emmanuel; Jagannathan, Prasanna et al. (2018) Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure. Elife 7:
Nankabirwa, Joaniter I; Briggs, Jessica; Rek, John et al. (2018) Persistent parasitemia despite dramatic reduction in malaria incidence after 3 rounds of indoor residual spraying in Tororo, Uganda. J Infect Dis :

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