The primary goal of this core is to identify, develop and evaluate promising research efforts that relate to the broad mission of the proposed center at Dartmouth Medical School. Pilot projects to be selected for support under this Core will be those deemed to have the scientific potential for eventual development as independent projects and which are well enough defined in terms of their goals and products to be evaluated at least annually for further funding. We proposed to fund up to two pilot projects per year, for an annual maximum of $50,000 per project, with the potenfial for being renewed once for a total of two years per project. (The total amount awarded under this core, for new or confinuing projects, is $100,000.) Pilot projects that are considered to have a high potenfial for scientific achievement after two years of funding will be considered further for funding in other core budgets and otherwise encouraged and assisted to seek addifional funding. We will solicit proposals for pilot projects, using a variety of methods including the Center's website, direct emailed solicitations of projects internal to Dartmouth Medical School and our collaborating academic institufions, and targeted invitations to potential invesfigators identified by our Pilot Project Scientific Review Committee. The review committee for this pilot project core will consist of the directors of all the cores and the PIs of all the projects plus a distinguished radiation physicist. The review committee will meet annually and as needed to review applications and to evaluate the progress of pilot projects seeking addifional funding.
This pilot project core should add significantly to the misison of the CMCRs, seeking out and supporting promising approaches that will advance the capability of effectively and efficiently carrying out triage after a large scale event. The focus within the center on such dosimetry should provide a very supporting and synergistic pathway to rapid progress.
|Rogan, Peter K; Li, Yanxin; Wickramasinghe, Asanka et al. (2014) Automating dicentric chromosome detection from cytogenetic biodosimetry data. Radiat Prot Dosimetry 159:95-104|
|Sidabras, Jason W; Varanasi, Shiv K; Mett, Richard R et al. (2014) A microwave resonator for limiting depth sensitivity for electron paramagnetic resonance spectroscopy of surfaces. Rev Sci Instrum 85:104707|
|Swartz, Harold M; Flood, Ann Barry; Williams, Benjamin B et al. (2014) Comparison of the needs for biodosimetry for large-scale radiation events for military versus civilian populations. Health Phys 106:755-63|
|Williams, Benjamin B; Flood, Ann Barry; Salikhov, Ildar et al. (2014) In vivo EPR tooth dosimetry for triage after a radiation event involving large populations. Radiat Environ Biophys 53:335-46|
|Ivannikov, Alexander I; Skvortsov, Valeri G; Stepanenko, Valeri F et al. (2014) Comparative analysis between radiation doses obtained by EPR dosimetry using tooth enamel and established analytical methods for the population of radioactively contaminated territories. Radiat Prot Dosimetry 159:125-9|
|Junwang, Guo; Qingquan, Yuan; Jianbo, Cong et al. (2014) New developed cylindrical TM010 mode EPR cavity for X-band in vivo tooth dosimetry. PLoS One 9:e106587|
|Flood, Ann Barry; Boyle, Holly K; Du, Gaixin et al. (2014) Advances in a framework to compare bio-dosimetry methods for triage in large-scale radiation events. Radiat Prot Dosimetry 159:77-86|
|Swartz, Harold M; Williams, Benjamin B; Zaki, Bassem I et al. (2014) Clinical EPR: unique opportunities and some challenges. Acad Radiol 21:197-206|
|He, Xiaoming; Swarts, Steven G; Demidenko, Eugene et al. (2014) Development and validation of an ex vivo electron paramagnetic resonance fingernail biodosimetric method. Radiat Prot Dosimetry 159:172-81|
|Swartz, Harold M; Williams, Benjamin B; Flood, Ann Barry (2014) Overview of the principles and practice of biodosimetry. Radiat Environ Biophys 53:221-32|
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