Abstract

In the next 5 years of the NURSA project, we will carry out a series of advanced data acquisitions that willprovide a proteomic atlas for the 'systems biology' of signal-regulated NR pathways in vivo. Such highthroughputdata acquisition projects are not themselves possible as R01 mechanisms, yet the accumulateddata will greatly stimulate hypothesis-driven research in the entire field of nuclear receptor science. We willpursue the isolation and identification of coregulator (CoR) complexes in mouse tissues, improving protocolsFor generating protein extracts from mouse tissues of liver, adipocytes, uterus and brain for proteomicanalyses, and isolating and identify coregulator protein complexes from mouse tissues for analysis by massspec. We will carry out profiling of post-translational modifications (PTM) of coregulator complexes and wewill also profile coordinated PTMs of NR and CoRs following physiologic signaling.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19DK062434-06
Application #
7350635
Study Section
Special Emphasis Panel (ZDK1-GRB-9 (M1))
Project Start
2007-08-01
Project End
2012-07-31
Budget Start
2007-09-01
Budget End
2008-07-31
Support Year
6
Fiscal Year
2007
Total Cost
$155,288
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Kim, Kang Ho; Choi, Sungwoo; Zhou, Ying et al. (2017) Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice. Hepatology 66:498-509
Fleet, Tiffany; Stashi, Erin; Zhu, Bokai et al. (2016) Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. J Biol Rhythms 31:443-60
Wagner, Martin; Choi, Sungwoo; Panzitt, Katrin et al. (2016) Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology 63:95-106
Han, Sang Jun; Begum, Khurshida; Foulds, Charles E et al. (2016) The Dual Estrogen Receptor ? Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol 89:14-26
Han, Sang Jun; Jung, Sung Yun; Wu, San-Pin et al. (2015) Estrogen Receptor ? Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell 163:960-74
Wu, San-Pin; Kao, Chung-Yang; Wang, Leiming et al. (2015) Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun 6:8245
Tang, Ke; Tsai, Sophia Y; Tsai, Ming-Jer (2015) COUP-TFs and eye development. Biochim Biophys Acta 1849:201-9
Xu, Pingwen; Cao, Xuehong; He, Yanlin et al. (2015) Estrogen receptor-? in medial amygdala neurons regulates body weight. J Clin Invest 125:2861-76
Kang, Yun Kyoung; Putluri, Nagireddy; Maity, Suman et al. (2015) CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-?-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet 11:e1005116
Kida, Yasuyuki S; Kawamura, Teruhisa; Wei, Zong et al. (2015) ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. Cell Stem Cell 16:547-55

Showing the most recent 10 out of 214 publications