The Administrative Core provides centralized offices for the coordination of the Yale Mouse Metabolic Phenotypic Center (MMPC) research activities. The Administrative Core operates under the supervision of the Program Director and the Associate Program Director. The principle functions of the Administrative Core are as follows: ?Administrative and Financial Management ?Prioritization of Scientific Core usage by Users ?Coordination for Importing Mice from Extramural Institutions ?Material Transfer Agreements ?Cost sharing for use of the Scientific Cores ?Data Exchange and Confidentiality ?Feedback and Quality Control ?Administration ofthe Pilot and Feasibility Project Program ?Provision of a Scientific Enrichment Program ?Maintenance ofthe Yale MMPC Web Page ?Maintenance ofthe Yale MMPC Data Base ?Education and Training ? Research and Development In consultation with the MMPC/ AMDCC Coordinating and Bioinformatics Unit, the Administrative Core also maintains Center budgetary and workflow records;oversees the importation and workflow assignments for strains submitted for services;establishes, standardizes, documents and distributes phenotyping protocols; and provides for quality control and budgetary oversight. Whereas the significance and quality of the Yale MMPC is defined by its phenotyping cores, the Administrative Core promotes efficient operation of the Center and ensures its vitality and success.

Public Health Relevance

The Administrative Core provides centralized offices for the coordination of the Yale Mouse Metabolic Phenotypic Center (MMPC) research activities. It is anticipated that the results obtained from characterizing these mice at the Yale MMPC will provide important new insights into the pathogenesis and complications relating to diabetes and obesity in humans.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Special Emphasis Panel (ZDK1-GRB-S)
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Yale University
New Haven
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Feriod, Colleen N; Oliveira, Andre Gustavo; Guerra, Mateus T et al. (2017) Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. Hepatol Commun 1:23-35
Kory, Nora; Grond, Susanne; Kamat, Siddhesh S et al. (2017) Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J Lipid Res 58:226-235
Camporez, João Paulo; Wang, Yongliang; Faarkrog, Kasper et al. (2017) Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice. Proc Natl Acad Sci U S A 114:E11285-E11292
von Loeffelholz, Christian; Lieske, Stefanie; Neuschäfer-Rube, Frank et al. (2017) The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism. Hepatology 66:616-630
Perry, Rachel J; Peng, Liang; Cline, Gary W et al. (2017) Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nat Commun 8:798
Corbit, Kevin C; Camporez, João Paulo G; Tran, Jennifer L et al. (2017) Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. JCI Insight 2:e91001
Li, Yuwen; Caballero, Daniel; Ponsetto, Julian et al. (2017) Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One 12:e0176232
Jelenik, Tomas; Kaul, Kirti; Séquaris, Gilles et al. (2017) Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver. Diabetes 66:2241-2253
Sun, Emily W; de Fontgalland, Dayan; Rabbitt, Philippa et al. (2017) Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine. Diabetes 66:2144-2149
Caballero, Daniel; Li, Yuwen; Fetene, Jonathan et al. (2017) Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice. PLoS One 12:e0180098

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