The Differentiation, Genetic Repair and Reporter Core will introduce essential new approaches to directed IPS cell differentiation, human genomic editing and cell purification for an emerging disease modeling technology. The Differentiation, Genetic Repair and Reporter Core is closely integrated with the Reprogramming CROs (Harvard Stem Cell Institute and New York Stem Cell Foundation) and the Cell Function and Pathophysiology Core to transition high quality patient-specific iPS cell lines into assays to examine the vulnerability of ventral midbrain (VM) dopaminergic (DA) neurons derived from patients with genetic forms of PD for translational research and drug discovery. The PDiPS Consortium plan is to use more resources and budget for this core in year 1 in order to accelerate the work to provide new protocols, training and genetically repaired iPS cells with reporters for the entire consortium. In year 2, the focus will be on collaboration and scientific needs for laboratories that may require differentiated cells into neurons prior to shipment to their laboratories.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24NS078338-02
Application #
8551306
Study Section
Special Emphasis Panel (ZNS1-SRB-S)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$168,924
Indirect Cost
$25,448
Name
Mclean Hospital
Department
Type
DUNS #
046514535
City
Belmont
State
MA
Country
United States
Zip Code
02478