Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
1U24NS078370-01
Application #
8295046
Study Section
Special Emphasis Panel (ZNS1-SRB-S (53))
Project Start
2012-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$662,213
Indirect Cost
$60,111
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Haston, Kelly M; Finkbeiner, Steven (2016) Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases. Annu Rev Pharmacol Toxicol 56:489-510
Mattis, Virginia B; Tom, Colton; Akimov, Sergey et al. (2015) HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet 24:3257-71
Hatada, Seigo; Subramanian, Aparna; Mandefro, Berhan et al. (2015) Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. Stem Cells Transl Med 4:998-1010
Finkbeiner, Steven; Frumkin, Michael; Kassner, Paul D (2015) Cell-based screening: extracting meaning from complex data. Neuron 86:160-74
Shelley, Brandon C; Gowing, Geneviève; Svendsen, Clive N (2014) A cGMP-applicable expansion method for aggregates of human neural stem and progenitor cells derived from pluripotent stem cells or fetal brain tissue. J Vis Exp :
Barmada, Sami J; Serio, Andrea; Arjun, Arpana et al. (2014) Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat Chem Biol 10:677-85
Skibinski, Gaia; Nakamura, Ken; Cookson, Mark R et al. (2014) Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J Neurosci 34:418-33
Ross, Christopher A; Akimov, Sergey S (2014) Human-induced pluripotent stem cells: potential for neurodegenerative diseases. Hum Mol Genet 23:R17-26
Sun, Yaping; Dong, Zhiqiang; Jin, Taihao et al. (2013) Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife 2:e00508
Kaye, Julia A; Finkbeiner, Steven (2013) Modeling Huntington's disease with induced pluripotent stem cells. Mol Cell Neurosci 56:50-64